518 results found
    1. Cell Biology
    2. Immunology and Inflammation

    Sequence specific detection of bacterial 23S ribosomal RNA by TLR13

    Xiao-Dong Li, Zhijian J Chen
    A pattern recognition receptor called toll-like receptor 13 detects pathogens in a manner that is different to that seen in other pathogen sensors.
    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    Cancer: How does doxorubicin work?

    Anand G Patel, Scott H Kaufmann
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    1. Developmental Biology
    2. Neuroscience

    LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans

    Pengpeng Li et al.
    The Notch signaling pathway has a central role in the formation of the circuit that controls egg-laying in the nematode worm C. elegans.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

    Joshua T Schiffer et al.
    A combination of detailed sampling and mathematical modeling suggests that the response of immune cells to reactivation of herpes simplex virus 2 is extremely rapid and effective within microscopic areas of genital skin.
    1. Cell Biology

    The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress

    Yingying Zhao et al.
    Ubiquitin ligase adaptors target the selective clearance of misfolded plasma membrane proteins.
    1. Neuroscience

    Dismantling the Papez circuit for memory in rats

    Seralynne D Vann
    In contrast to current models, inputs from midbrain limbic structures, but not from the hippocampus, are necessary for mammillary body contributions to memory.
    1. Cell Biology
    2. Developmental Biology

    Apical targeting of the formin Diaphanous in Drosophila tubular epithelia

    Tal Rousso et al.
    Synergistic interactions with PI(4,5)P2 and activated Rho1, which are enriched at the apical membrane of tubular organs, facilitate tight apical targeting of the formin Diaphanous.
    1. Cell Biology
    2. Immunology and Inflammation

    MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

    Siqi Liu et al.
    A cell-free system combined with cell-based assays elucidate the biochemical mechanism of signal transduction mediated by the mitochondrial protein MAVS and delineates the role of ubiquitin E3 ligases in antiviral innate immune responses.
    1. Developmental Biology
    2. Neuroscience

    APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice

    Hong Y Choi et al.
    Proteins implicated in Alzheimer’s disease, including amyloid precursor protein and ApoE receptors, interact with each other and with a signalling molecule called agrin to influence the development of the neuromuscular junction.

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