476 results found
    1. Structural Biology and Molecular Biophysics

    Structure of the human lipid-gated cation channel TRPC3

    Chen Fan et al.
    Cryo-EM structure reveals architecture, lipid-binding sites, and ion-conducting pore of the human TRPC3 cation channel.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

    Javier García-Nafría et al.
    The adenosine A2a receptor couples to the heterotrimeric G protein Gs using both conserved contacts seen in other complexes and, in addition, novel contacts to the beta subunit of the G protein.
    1. Microbiology and Infectious Disease

    Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins

    Nitzan Koppel et al.
    A unique, widely distributed gut bacterial enzyme selectively metabolizes plant-derived cardiac glycoside drugs.
    1. Developmental Biology and Stem Cells

    Ripply2 recruits proteasome complex for Tbx6 degradation to define segment border during murine somitogenesis

    Wei Zhao et al.
    Inducing presomitic mesoderm (PSM)-fated ES cells clarified that Ripply2 directly interacts with Tbx6 and degrades Tbx6 in proteasome-ubiquitin pathway by recruiting the 26S proteasome, which is a PSM-specific event to define the segment border during mouse somitogenesis.
    1. Developmental Biology and Stem Cells

    Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish

    Almary Guerra et al.
    A discovery of two previously unknown, molecularly distinct fields of cardiac progenitors in zebrafish provides evidence for cardiac laterality prior to the emergence of cardiac septation and allows novel insights into cardiac development and disease.
    1. Structural Biology and Molecular Biophysics

    Electron cryo-microscopy structure of the canonical TRPC4 ion channel

    Deivanayagabarathy Vinayagam et al.
    Structural insights into the architecture and functional properties of zebrafish TRPC4 are revealed by high-resolution cryo-EM.
    1. Developmental Biology and Stem Cells

    Specialized impulse conduction pathway in the alligator heart

    Bjarke Jensen et al.
    A specialized conduction pathway for the electrical impulse in the heart, previously thought to be associated with the endothermic mammals and birds only, is also present in the ectothermic crocodiles.
    1. Developmental Biology and Stem Cells

    Evolution: The beat goes on

    Tobias Wang
    Why is the alligator heart so similar to the hearts of birds and mammals?
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    1. Neuroscience

    Stomach-brain synchrony reveals a novel, delayed-connectivity resting-state network in humans

    Ignacio Rebollo et al.
    Coupling between the gastric rhythm and brain activity at rest reveals a novel resting-state network, characterized by delayed functional connectivity.

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