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    1. Developmental Biology

    Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

    Haruko Nakano et al.
    During cardiogenesis, the major role of glucose is not the catabolic extraction of energy but the anabolic biosynthesis of nucleotides.
    1. Cell Biology
    2. Developmental Biology

    Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos

    Amanda D Yzaguirre et al.
    Ras-GAP activity suppresses the hemogenic potential of the embryonic heart.
    1. Cell Biology
    2. Developmental Biology

    Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death

    Fabrice Bouilloux et al.
    The transcription factor Meis1 is a dedicated maintenance factor for sympathetic neurons and controls the expression of key genes involved in endosome trafficking.
    1. Cell Biology

    Profound regulation of Na/K pump activity by transient elevations of cytoplasmic calcium in murine cardiac myocytes

    Fang-Min Lu et al.
    Transient Ca elevations of cytoplasmic calcium in cardiac myocytes profoundly activate cardiac Na/K pump activity in parallel with physical-chemical changes of the sarcolemma but without involvement of conventional signaling mechanisms.
    1. Cell Biology
    2. Human Biology and Medicine

    KChIP2 is a core transcriptional regulator of cardiac excitability

    Drew M Nassal et al.
    The ion channel accessory subunit KChIP2 has a transcriptional role that provides regulation over miRNA targets, driving the adverse remodeling of key ion channels during cardiac stress and leading to the development of arrhythmia.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm

    Xinan H Yang et al.
    Transcription-factor-dependent noncoding RNA transcription illuminates components of a transcription-factor-dependent gene regulatory network that includes enhancer-associated long noncoding RNAs and is necessary for cardiac rhythm.
    1. Cell Biology
    2. Developmental Biology

    Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity

    Hirohito Shimizu et al.
    Enhancing mitochondrial Ca2+ uptake effectively suppresses aberrant Ca2+ induced arrhythmogenic events in zebrafish, mouse and human cardiomyocytes, demonstrating a critical role for mitochondria in the regulation of cardiac rhythmicity.
    1. Developmental Biology

    Reciprocal analyses in zebrafish and medaka reveal that harnessing the immune response promotes cardiac regeneration

    Shih-Lei Lai et al.
    Timely macrophage recruitment is essential for neovascularization and neutrophil clearance during cardiac regeneration.
    1. Developmental Biology

    Early patterning and specification of cardiac progenitors in gastrulating mesoderm

    W Patrick Devine et al.
    Multipotent cardiac precursors within a population of mesoderm are rapidly fated to specific anatomic locations in the developing mouse heart.
    1. Human Biology and Medicine

    Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

    Lorenzo Alamo et al.
    Mapping the locations of hypertrophic cardiomyopathy gene variants onto the three-dimensional structures of contractile proteins revealed that these disrupt protein interactions are critical for normal cardiac relaxation and efficient energy usage.