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    1. Developmental Biology

    Reciprocal analyses in zebrafish and medaka reveal that harnessing the immune response promotes cardiac regeneration

    Shih-Lei Lai et al.
    Timely macrophage recruitment is essential for neovascularization and neutrophil clearance during cardiac regeneration.
    1. Developmental Biology

    Early patterning and specification of cardiac progenitors in gastrulating mesoderm

    W Patrick Devine et al.
    Multipotent cardiac precursors within a population of mesoderm are rapidly fated to specific anatomic locations in the developing mouse heart.
    1. Cell Biology
    2. Developmental Biology

    Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity

    Hirohito Shimizu et al.
    Enhancing mitochondrial Ca2+ uptake effectively suppresses aberrant Ca2+ induced arrhythmogenic events in zebrafish, mouse and human cardiomyocytes, demonstrating a critical role for mitochondria in the regulation of cardiac rhythmicity.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm

    Xinan H Yang et al.
    Transcription-factor-dependent noncoding RNA transcription illuminates components of a transcription-factor-dependent gene regulatory network that includes enhancer-associated long noncoding RNAs and is necessary for cardiac rhythm.
    1. Human Biology and Medicine

    Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

    Lorenzo Alamo et al.
    Mapping the locations of hypertrophic cardiomyopathy gene variants onto the three-dimensional structures of contractile proteins revealed that these disrupt protein interactions are critical for normal cardiac relaxation and efficient energy usage.
    1. Neuroscience

    Two central pattern generators from the crab, Cancer borealis, respond robustly and differentially to extreme extracellular pH

    Jessica A Haley et al.
    The rhythms generated by the stomatogastric and cardiac ganglia of the Jonah crab are surprisingly robust but differentially sensitive to acute changes in extracellular pH from pH 5.5 to 10.4.
    1. Stem Cells and Regenerative Medicine

    Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish

    Matthew Gemberling et al.
    Neuregulin1 is induced upon cardiac injury in adult zebrafish, and is sufficient to drive massive proliferative growth of the heart.
    1. Developmental Biology

    Revised roles of ISL1 in a hES cell-based model of human heart chamber specification

    Roberto Quaranta et al.
    Loss and gain-of-function investigation uncovers a regulatory network controlling human heart chamber specification in which the cardiac precursor gene ISL1 accelerates ventricular induction and antagonizes retinoic acid-driven atrial commitment.
    1. Cell Biology

    The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

    Catherine A Makarewich et al.
    Cardiac-specific overexpression of a recently discovered micropeptide, DWORF, enhances calcium cycling and contractility in the heart and rescues the heart failure phenotype of a genetic mouse model of dilated cardiomyopathy.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    The Ca2+ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations

    Colin M Rees et al.
    Feedback sensing of the intracellular calcium concentration suffices to reproduce the diversity of ionic conductances underlying normal cardiac electromechanical function in a genetically diverse population of mice.