56 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The magnesium transporter A is activated by cardiolipin and is highly sensitive to free magnesium in vitro

    Saranya Subramani et al.
    A magnesium transporter from Escherichia coli depends strongly on the lipid cardiolipin and acts both as a sensor and a transporter of magnesium.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture

    Max Emanuel Harner et al.
    Interactions between Aim24 and the mitochondrial outer and inner membrane contact site complex (MICOS) are essential for mitochondrial ultrastructure, lipid composition and oxidative phosphorylation.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Structure of a mitochondrial ATP synthase with bound native cardiolipin

    Alexander Mühleip et al.
    The atomic model of a mitochondrial ATP synthase dimer underlies functions of its specific protein constituents and boundary cardiolipins.
    1. Cell Biology

    MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture

    Jonathan R Friedman et al.
    A conserved mitochondrial inner membrane complex called MICOS works together with the mitochondrial lipid cardiolipin and respiratory complexes to direct the position, copy number and stabilization of cristae structures for efficient respiration.
    1. Microbiology and Infectious Disease

    Insect endosymbiont proliferation is limited by lipid availability

    Jeremy K Herren et al.
    The endosymbiont Spiroplasma can only proliferate if it can acquire sufficient hemolymph lipids from its insect host.
    1. Microbiology and Infectious Disease

    Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

    Suneeta Chimalapati et al.
    Considering the course of a pathogen's evolution, there appears to be interplay between secretion systems, providing unique, synergistic mechanisms to support a successful lifestyle for possibly pathogenesis, symbiosis and/or parasitosis.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding

    Danyang Zhang et al.
    GTP binding induces rearrangement of S-OPA1 assembly on membrane and thus triggers membrane remodeling with reduced curvature.
    1. Medicine

    Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

    Ying Ann Chiao et al.
    Mitochondrial-targeted SS-31 peptide ameliorates mitochondrial dysfunction and rescues pre-existing cardiac dysfunction in old mice, supporting the translational potential of mitochondrial protective interventions to treat age-related diseases.
    1. Cell Biology

    Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

    Huiliang Zhang et al.
    The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).
    1. Evolutionary Biology

    Membranes, energetics, and evolution across the prokaryote-eukaryote divide

    Michael Lynch, Georgi K Marinov
    The common view that the mitochondrion endowed eukaryotes with a boost in bioenergetic capacity above that in prokaryotes is inconsistent with a diversity of cellular features.

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