101 results found
    1. Developmental Biology

    In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration

    Mira I Pronobis et al.
    Proximity labeling-based proteomic strategies applied in zebrafish identify new insights into protein network changes in heart muscle cells during regeneration and implicate Rho A as a target of ErbB2 signaling during zebrafish heart regeneration.
    1. Cell Biology

    Generation of stress fibers through myosin-driven reorganization of the actin cortex

    Jaakko I Lehtimäki et al.
    Live-cell microscopy studies revealed that stress fibers can be generated de novo from the actin cortex without the involvement of stress fiber precursors.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    To lie or not to lie: Super-relaxing with myosins

    Suman Nag, Darshan V Trivedi
    A perspective of the energy-sparing super-relaxed state of myosin and its evolutionary role in modulating skeletal and cardiac muscle power under different physiological and pathophysiological perturbations.
    1. Neuroscience
    2. Physics of Living Systems

    Random access parallel microscopy

    Mishal Ashraf et al.
    A new imaging modality is described that can simultaneously record from several dishes without using robotics, which enables researchers to perform high-throughput, continuous measurements on biological samples.
    1. Computational and Systems Biology

    Drift and termination of spiral waves in optogenetically modified cardiac tissue at sub-threshold illumination

    Sayedeh Hussaini et al.
    Excitability gradients in heart tissue, imposed by structured sub-threshold optogenetic stimulation, induce drift and termination of spiral waves, thus providing an explanation for successful optogenetic defibrillation in small animal hearts.
    1. Computational and Systems Biology

    Cardiac Optogenetics: A move in the light direction

    Eike M Wülfers, Franziska Schneider-Warme
    Computer simulations show how low-intensity illumination can be used to terminate cardiac arrhythmias.
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    1. Cell Biology

    Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

    Huiliang Zhang et al.
    The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Spatially compartmentalized phase regulation of a Ca2+-cAMP-PKA oscillatory circuit

    Brian Tenner et al.
    Nanodomain clustering of cAMP effectors represents a novel mechanism of cAMP compartmentation within an oscillatory signaling circuit.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction

    Laura Alonso-Herranz et al.
    Macrophage production of MT1-MMP upon MI contributes to adverse cardiac remodeling and worsened function by promoting EndMT via TGFB, suggesting MT1-MMP inhibition as a therapeutic option for patients with MI.
    1. Structural Biology and Molecular Biophysics

    Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation

    Georg Kuenze et al.
    An integrative structural biology approach provides refined models of the KCNQ1-KCNE1 channel complex, which propose a new mechanism to explain how KCNE1 modulates KCNQ1 channel activation.

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