101 results found
    1. Developmental Biology

    The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling

    Seyed Javad Rasouli et al.
    Endocardial Klf2 regulates cardiomyocyte adhesion and myocardial wall integrity by modulating FGF signaling in zebrafish.
    1. Cell Biology
    2. Developmental Biology

    Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion

    Yfat Yahalom-Ronen et al.
    Compliant matrix provides a permissive micoenvironment for cardiomyocyte dedifferentiation, cell division and expansion, and thus may open a new avenue towards cardiac regeneration.
    1. Cell Biology
    2. Developmental Biology

    Metabolic modulation regulates cardiac wall morphogenesis in zebrafish

    Ryuichi Fukuda et al.
    3D single cell imaging and genetic analyses reveal a new role of cardiac metabolism in cardiac wall morphogenesis.
    1. Developmental Biology

    Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis

    Kenzo Ivanovitch et al.
    Tissue-level coordination of cardiac progenitor cells in the early mouse embryo produces a temporal compartmentalization of differentiation and morphogenesis essential for heart tube formation.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia

    Fransky Hantelys et al.
    In mouse cardiomyocytes, (lymph)angiogenic growth factors are induced during early hypoxia by a translational mechanism involving a new IRES trans-acting factor, vasohibin-1.
    1. Structural Biology and Molecular Biophysics

    Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations

    Sara I Liin et al.
    Fatty acid analogues are interesting prototype compounds that may inspire the development of future IKs channel activators to treat patients with long QT syndrome caused by diverse arrhythmia-causing mutations in the IKs channel.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system

    Rupamanjari Majumder et al.
    Free optical steering of spiral waves by attraction-based dragging of their cores in optogenetically modified cardiac tissue.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    The Ca2+ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations

    Colin M Rees et al.
    Feedback sensing of the intracellular calcium concentration suffices to reproduce the diversity of ionic conductances underlying normal cardiac electromechanical function in a genetically diverse population of mice.
    1. Cell Biology

    Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination

    Eric Seemann et al.
    Mice lacking the membrane-shaping protein syndapin III show severe reduction of caveolae reminiscent of human caveolinopathies but maintain plasma membrane-associated caveolar coats proteins and thereby unveil physiological impairments associated with lack of invaginated caveolae.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating

    Rupamanjari Majumder et al.
    Customization of ion channel gating enhances homeostatic regulation through automatic detection and correction of abnormal physiological changes, as illustrated by self-restoration of excitation rhythm in cardiac arrhythmias.

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