4,732 results found
    1. Cell Biology
    2. Neuroscience

    FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model

    Tae-In Kam et al.
    By binding to Fc gamma receptor IIb, amyloid beta induces a series of phosphorylation events that mediate the damaging effects of hyperphosphorylated tau proteins in Alzheimer's disease.
  1. Point of View: Overflow in science and its implications for trust

    Sabina Siebert et al.
    Interviews with senior biomedical researchers reveal a perceived decline in trust in the scientific enterprise, in large part because the quantity of new data exceeds the field's ability to process it appropriately.
  2. Living Science: The humanity of science

    Indira M Raman
    Science can provide cures and improve health, and it can also make us more humane.
  3. Living Science: The truth is in the distribution

    Indira M Raman
    There may be as many ways to think about the experience of women in science as there are women in science.
  4. Cutting Edge: Science hackathons for developing interdisciplinary research and collaborations

    Derek Groen, Ben Calderhead
    Science hackathons can help academics, particularly those in the early stage of their careers, to build collaborations and write research proposals.
    1. Microbiology and Infectious Disease

    Point of View: What next for gain-of-function research in Europe?

    Robin Fears, Volker ter Meulen
    A EASAC working group on gain-of-function research has emphasised the importance of ensuring that the necessary safeguards and policies are in place.
  5. Point of View: Making science count in government

    Ian Boyd
    Science is an essential component of policy-making in most areas of government, but the scientific community does not always understand its role in this process.
  6. Point of View: How should novelty be valued in science?

    Barak A Cohen
    An over-emphasis on novelty is having detrimental effects on science.
  7. Research: Decoupling of the minority PhD talent pool and assistant professor hiring in medical school basic science departments in the US

    Kenneth D Gibbs Jr et al.
    A systems-level analysis of the biomedical workforce in the US shows that current strategies to enhance faculty diversity are unlikely to have a significant impact, and that there is a need to increase the number of PhDs from underrepresented minority backgrounds who move on to postdoctoral positions.
    1. Developmental Biology and Stem Cells
    2. Genes and Chromosomes

    Science Forum: Considerations when investigating lncRNA function in vivo

    Andrew R Bassett et al.
    We discuss the methods available to understand lncRNA function in vivo, and highlight important considerations that should be taken into account when designing such experiments.

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