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Immunology and Inflammation
Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death
Jack Gisby et al.
Severe COVID-19 is characterised by a plasma proteomic biomarker signature, indicating innate immune activation, leucocyte–endothelial interactions, and epithelial injury.
Research Culture: A survey-based analysis of the academic job market
Jason D Fernandes et al.
A survey of over 300 applicants for faculty positions reveals that there are many paths to securing a job offer.
Research Culture: A survey of early-career researchers in Australia
Katherine Christian et al.
Job insecurity is putting stress on early-career researchers in Australia, compromising their career development and potentially reducing the quality of research.
Microbiology and Infectious Disease
Research Culture: Co-reviewing and ghostwriting by early-career researchers in the peer review of manuscripts
Gary S McDowell et al.
Early career researchers commonly peer review manuscripts on behalf of invited reviewers, often without receiving feedback or being named to the journal.
Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAF
J Edward van Veen et al.
Two of the most commonly mutated growth factor pathways induce a deadly feature of lung adenocarcinoma.
Immunology and Inflammation
Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception
Stefanie Gryzik et al.
A novel binning approach provides evidence for super-functional T cells with high activation potential and which exhibit Tfh-like functionalities and can help B cells.
Stem Cells and Regenerative Medicine
Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation
Chee Wai Chua et al.
Analyses of genetically engineered mouse models reveal the androgen receptor-independent properties of a luminal stem/progenitor cell in the prostate epithelium, and its ability to serve as a cell of origin for castration-resistant prostate cancer.
Chromosomes and Gene Expression
The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer
Eric Wang et al.
TRIM33 performs an essential function in B cell acute lymphoblastic leukemia through an association with a single
Biochemistry and Chemical Biology
Genetics and Genomics
The long non-coding RNA
is a post transcriptional regulator of mitochondrial complex I catalytic activity
Tamara M Sirey et al.
Mitochondrial energy metabolism is post-transcriptionally regulated through an interplay between long and short non-coding RNAs.
Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis
Preetish Kadur Lakshminarasimha Murthy et al.
Fringe proteins regulate Notch pathway differentially in the stem cell zone and progenitor compartment of the mouse intestinal epithelium to promote homeostasis.
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