Co-evolving residue pairs in the different components of a protein complex almost always make contact across the protein–protein interface, thus providing powerful restraints for the modeling of protein complexes.

Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.

Host characteristics drive the assembly of similar communities within the convergently evolved and geographically distant pitcher ecosystems of carnivorous pitcher plants.

Mathematical and experimental analyses suggest that despite their complex architectures, multiple metazoan signaling pathways act in physiological contexts as linear signal transmitters.

Hemodynamic forces regulate endothelial cell metabolism, which in turn regulates endothelial inflammation.

Age-dependent protein aggregation closely resembles protein aggregation associated with neurodegenerative diseases and other amyloidoses, and initiates early functional decline in different tissues.

Shugoshin proteins help to align chromosomes so that copies of the same chromosome attach to microtubules from opposite poles during cell division.

NIFK promotes lung cancer metastasis via Runx1-dependent repression of CK1α, which activates TCF4/β-catenin signaling.

Casein kinase I, a pivotal kinase in the circadian clock encoded by ck-1a, is positively regulated by a novel RNA-binding protein that protects ck-1a transcripts from nonsense-mediated decay.

Proximity labeling-based proteomic strategies applied in zebrafish identify new insights into protein network changes in heart muscle cells during regeneration and implicate Rho A as a target of ErbB2 signaling during zebrafish heart regeneration.