166 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Secondary ossification center induces and protects growth plate structure

    Meng Xie et al.
    The principle underlying the appearance of the growth plate, an organ responsible for longitudinal growth, has implications for various cartilage pathologies including growth abnormalities in children, trauma and osteoarthritis.
    1. Cell Biology

    Complementary α-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids

    Vasyl Ivashov et al.
    Metabolic cues enlist ubiquitin ligase adaptors for the selective control of cellular nutrient acquisition strategies.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

    Tatyana Bodrug et al.
    Biochemical, single molecule, cell and structural biology studies reveal an interaction between the kinesin-5 tail and motor domains regulating high-force production, which is critical for microtubule sliding motility.
    1. Genetics and Genomics

    Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

    Niko Välimäki et al.
    Genetic predisposition to uterine leiomyomas arises from variation at loci for genetic stability and genitourinary development, and in part explains the frequent occurrence of the condition in women with African origin.
    1. Cell Biology

    The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

    Matthew J Shurtleff et al.
    The ER membrane protein complex promotes the biogenesis of a subset multipass membrane proteins enriched for transporters and other proteins with destabilizing features in transmembrane domains.
    1. Neuroscience

    Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies

    Efrén Álvarez-Salvado et al.
    A high-throughput behavioral paradigm and computational modeling are used to decompose olfactory navigation in walking Drosophila melanogaster into a set of quantitative relationships between sensory input and motor output.
    1. Cell Biology

    COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal

    Peng Xu et al.
    COPI vesicle coat protein recognizes a ubiquitin sorting signal on an exocytic v-SNARE to mediate recycling.
    1. Cell Biology

    Sec24 phosphorylation regulates autophagosome abundance during nutrient deprivation

    Saralin Davis et al.
    Phosphorylation of a core trafficking component, the COPII coat subunit Sec24, regulates cross-talk between the secretory and autophagy machinery during starvation.
    1. Genetics and Genomics

    The genetic basis for ecological adaptation of the Atlantic herring revealed by genome sequencing

    Alvaro Martinez Barrio et al.
    Whole genome sequencing of 19 populations of Atlantic and Baltic herring reveals hundreds of individual loci underlying adaptation to a low salinity niche or timing of reproduction.
    1. Neuroscience

    Drep-2 is a novel synaptic protein important for learning and memory

    Till F M Andlauer et al.
    Drep-2 is the first representative of the evolutionary conserved CIDE-N protein family found at synapses and is required for associative learning by functionally intersecting with metabotropic signaling.

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