394 results found
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A common bacterial metabolite elicits prion-based bypass of glucose repression

    David M Garcia et al.
    Activity-guided fractionation identifies the first bacterial metabolite that potently induces a prion in nature.
    1. Cell Biology
    2. Genetics and Genomics

    Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

    Siming Ma et al.
    Profiling of fibroblasts across mammals captures differences in longevity at the level of global gene expression and metabolite levels and reveals pathways that define these differences.
    1. Microbiology and Infectious Disease

    Transcriptome dynamics of the Myxococcus xanthus multicellular developmental program

    José Muñoz-Dorado et al.
    Investigation of global gene expression profiles during formation of the Myxococcus xanthus specialized biofilm reveals a genetic regulatory network that coordinates cell motility, differentiation, and secondary metabolite production.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

    Meredith A Sommars et al.
    B cell lymphoma 6 (BCL6) represses fasting gene expression by opposing peroxisome proliferator-activated receptor alpha (PPARa) activity at enhancers, and its ablation protects against steatosis by enhancing fatty acid catabolism.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Aging: Stressing about misplaced fat is a key to longevity

    George A Lemieux, Kaveh Ashrafi
    Insight
    Available as:
    • HTML
    • PDF
    1. Cell Biology

    Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases

    Kim Hou Chia et al.
    The Rag-family GTPases, known activators of TOR complex 1 (TORC1), also function as attenuator that prevents deregulated hyperactivation of TORC1 signaling.
    1. Plant Biology

    Antimicrobial peptide expression in a wild tobacco plant reveals the limits of host-microbe-manipulations in the field

    Arne Weinhold et al.
    The attempt to manipulate a microbiome in planta to study the ecological consequences under field conditions leaves plants and their microbes surprisingly unimpressed.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

    Richard S Marshall, Richard D Vierstra
    Proteasomes are protected from autophagic elimination upon carbon starvation by sequestration into cytoplasmic storage granules, which aid cell fitness by providing a cache of proteasomes that can be rapidly remobilized when carbon availability improves.
    1. Neuroscience

    Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure

    Aitak Farzi et al.
    CART exerts differential metabolic effects in response to activation of neurons of the Arc, where CART suppresses energy expenditure, while it enforces the reward characteristics of the LHA.

Refine your results by:

Type
Research categories