Prokaryotic TRADD-N and Death-like adaptor domains in diverse predicted apoptosis and immune systems from multicellular prokaryotes and metazoans indicate the common origin of key apoptosis mechanisms required for the stabilization of multicellularity.
Multiple mechanisms, by which a highly conserved chromatin-remodeling factor RSC facilitates initiation and maintenance of large-scale, rapid gene expression upon exit from quiescent state, have been discovered.
PDB-associated differences in DNA methylation are reproducible and reflect key environmental modulators of bone homeostasis including viral processes, vitamin D metabolism, as well as mechanical sheer load.
A spectroscopic analysis of the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-phospholamban membrane complex reveals the importance of the relative transmembrane orientation for inhibition or activation of the ATPase.
An immunofluorescent analysis of 465 protein kinases revealed a substantial role of liquid-liquid phase separation in kinase localization and identified new kinase localizations to mitochondria and other organelles.
Circuit and transcriptional analysis shows that genetically defined central amygdala neurons and their projections to the ventral periaqueductal gray mediate behavioral and affective responses to pruritus.
A 3D bone marrow niche that reproduces megakaryocyte differentiation and ex vivo platelet production from hematopoietic progenitors and iPSCs of thrombocytopenic patients predicts individual response to Eltrombopag accurately.
Cognitive reconstitution after pharmacologic unconsciousness is an extended process, executive function is more robust than expected, and the healthy human brain is resilient to the effects of deep general anesthesia.
A novel dimethylsulfoniopropionate lyase was identified, which catalyzes dimethyl sulfide releasing by a new mechanism and is found in several bacterial lineages, revealing its important roles in global sulfur cycling.