Unconventional secretion of a plasma membrane purine transporter via Golgi-bypass is established at an early ER-associated secretory compartment revealing that specific cargoes define alternative trafficking routes.

Membrane tension controls the dynamic assembly and disassembly of caveolae and their association with the F-actin cortex in migrating cells.

A comprehensive molecular characterization of Schlemm’s canal cells to date provides a wealth of molecular details.

A new native prion protein aggregation assay shows that syntaxin-6, a risk factor for sporadic Creutzfeldt–Jakob disease, delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates.