1,338 results found
    1. Immunology and Inflammation

    Thymic stromal lymphopoietin limits primary and recall CD8+ T-cell anti-viral responses

    Risa Ebina-Shibuya et al.
    Immunological analysis of wild-type and Crlf2-/- mice reveals a role for the cytokine thymic stromal lymphopoietin on memory CD8+ T-cell responses to viral infection, findings with potential translational implications.
    1. Immunology and Inflammation

    Empty conformers of HLA-B preferentially bind CD8 and regulate CD8+ T cell function

    Jie Geng et al.
    HLA-B*35:01 molecules that are peptide-deficient are thermostable, bind CD8 with higher affinity than their peptide-filled versions, accumulate at immunological synapses and enhance antigen-specific CD8+ T cell immune responses.
    1. Immunology and Inflammation
    2. Cell Biology

    Calcium-mediated shaping of naive CD4 T-cell phenotype and function

    Vincent Guichard et al.
    Calcium-calcineurin signaling cascade drives the acquisition of both the phenotype of the most self-reactive naive CD4 T cells and their enhanced cell-intrinsic ability to commit into induced regulatory T cells upon activation.
    1. Immunology and Inflammation

    TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance

    Marije Baas et al.
    The interplay between the cytokine TGFβ and the PD-1/PD-L1 pathway promotes CD8+ T cell anergy and tolerance towards transplanted tissues.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The viral context instructs the redundancy of costimulatory pathways in driving CD8+ T cell expansion

    Suzanne PM Welten et al.
    Redundancy in the costimulatory signals that drive CD8+ T cell expansion is dictated by pathogen-specific cues.
    1. Immunology and Inflammation

    Autophagy is a critical regulator of memory CD8+ T cell formation

    Daniel J Puleston et al.
    Autophagy is required for CD8+ T cell memory formation; in aged individuals autophagy levels are diminished, and increasing autophagy enhances their CD8+ T cell responses.
    1. Microbiology and Infectious Disease

    Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir

    Jason Neidleman et al.
    An in-depth view of the in vivo blood and tissue HIV reservoir is presented highlighting shared phenotypic features between individuals, thus enabling marked ex vivo enrichment of replication-competent latent cells.
    1. Immunology and Inflammation

    Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs

    Sofya A Kasatskaya et al.
    Functional subsets of helper CD4+ T cells carry TCR repertoires with distinct features that are reproducible across donors and are partially acquired at the level of thymic selection.
    1. Immunology and Inflammation

    Na+ influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation

    Yong Miao et al.
    Non-specific sodium entry inhibits T cell receptor induced gene expression and differentiation of T cells by depleting intracellular ATP and disrupting mTORC2 dependent signalling axis.
    1. Immunology and Inflammation

    Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice

    Neha R Deshpande et al.
    Higher affinity for self-pMHC complexes and broader promiscuity for foreign-pMHC complexes imparts a fitness advantage within the CD4+ T cell compartment in older mice.

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