5,375 results found
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Allosteric conformational ensembles have unlimited capacity for integrating information

    John W Biddle, Rosa Martinez-Corral ... Jeremy Gunawardena
    The effective higher-order binding cooperativities arising from an ensemble of dynamically interchanging conformations are identified and shown to fully describe integration of binding information at thermodynamic equilibrium.
    1. Neuroscience

    A role for descending auditory cortical projections in songbird vocal learning

    Yael Mandelblat-Cerf, Liora Las ... Michale S Fee
    Midbrain dopaminergic neurons and a cortex-like structure called the arcopallium form part of a circuit that enables young songbirds to compare their own song with a template stored in memory, and use any discrepancies to improve their performance.
    1. Neuroscience

    Distinct effects of prefrontal and parietal cortex inactivations on an accumulation of evidence task in the rat

    Jeffrey C Erlich, Bingni W Brunton ... Carlos D Brody
    Quantitative modeling of inactivations shows the prefrontal cortex (but not parietal cortex) of the rat is obligatory for decisions guided by evidence accumulating longer than 240 ms.
    1. Ecology
    2. Microbiology and Infectious Disease

    Multiple lineages of Streptomyces produce antimicrobials within passalid beetle galleries across eastern North America

    Rita de Cassia Pessotti, Bridget L Hansen ... Matthew F Traxler
    The widespread occurrence of metabolically active streptomycetes in Odontotaenius disjunctus beetle frass may insulate their galleries against pathogenic fungal invasion through the production of diverse antimicrobial specialized metabolites.
    1. Neuroscience

    Neural mechanisms of economic commitment in the human medial prefrontal cortex

    Konstantinos Tsetsos, Valentin Wyart ... Christopher Summerfield
    A striking dissociation exists in the medial prefrontal cortex, with different brain regions responding to value when commitments are deferred to the future and when prospects are judged to be undesirable.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Investigating the trade-off between folding and function in a multidomain Y-family DNA polymerase

    Xiakun Chu, Zucai Suo, Jin Wang
    The physical interaction network encoded in the multi-domain protein native structure handles the trade-off between the fast, stable folding and the efficient, reliable function.
    1. Neuroscience

    Finger somatotopy is preserved after tetraplegia but deteriorates over time

    Sanne Kikkert, Dario Pfyffer ... Nicole Wenderoth
    Hand somatotopy can be preserved in the primary somatosensory cortex of tetraplegic patients, despite the absence of sensorimotor function and periphery-brain communication, but deteriorates over years after injury.
    1. Neuroscience

    Using recurrent neural network to estimate irreducible stochasticity in human choice behavior

    Yoav Ger, Moni Shahar, Nitzan Shahar
    Applying deep learning tools to pinpoint predictive gaps in behavioral cognitive modeling.
    1. Neuroscience

    Eelbrain, a Python toolkit for time-continuous analysis with temporal response functions

    Christian Brodbeck, Proloy Das ... Jonathan Z Simon
    Brain activity is modelled as a function of stimuli that evolve continuously in time, in experimental designs without repeated trials.
    1. Neuroscience

    Functional topography of the human entorhinal cortex

    Tobias Navarro Schröder, Koen V Haak ... Christian F Doeller
    By employing high-field fMRI and taking advantage of well-known global connectivity fingerprints and sensitivity to spatial and non-spatial information, it is shown that the entorhinal cortex is primarily divided into anterior and posterior subregions.

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