Jae Yen Shin, Javier Lopez-Garrido ... Kit Pogliano
SpoIIIE forms a protein channel that spans the two lipid bilayers of the septum and mediates chromosome translocation and reversible membrane fission during Bacilus subtilis sporulation.
A newly identified pattern of circuit assembly shows connectivity between small groups of neurons born in tight time windows from different stem cells, with outputs from one lineage born before inputs from other lineages.
Nuclear pores assemble asymmetrically, by an inside-out evagination of the inner nuclear membrane that grows in diameter and depth until it fuses with the flat outer nuclear membrane.
In the cytosol, the proteins constituting cell-matrix adhesion sites form multi-protein building blocks which enter and leave these sites unaltered, thereby contributing to their rapid and correct self-assembly.
Analysis of protein interfaces suggests cotranslational assembly can be an adaptive process, likely serving to minimise non-specific interactions with other proteins in the cell.
As the function of membrane proteins is often influenced by its membrane environment the presented combinatorial approach is of great value for the investigation of membrane protein complexes in natural or even manipulated lipid bilayers.
Despite ongoing rewiring and continuous turnover of synapses, a computational model shows that memories can maintain and even strengthen their connectivity by self-reactivating during periods without sensory input.
Sonja Kroschwald, Shovamayee Maharana ... Simon Alberti
A comparison in yeast and human cells reveals a remarkable variability in the properties of RNP granules and highlights a key role for protein disaggregation machines in regulating RNP granule assembly.
