1,774 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

    Hannah K Long, David Sims ... Robert J Klose
    Islands of non-methylated DNA are shown to perform a similar epigenetic role in many different vertebrate species.
    1. Evolutionary Biology

    Whole genome phylogenies reflect the distributions of recombination rates for many bacterial species

    Thomas Sakoparnig, Chris Field, Erik van Nimwegen
    For many bacterial species, recombination dominates genome evolution and phylogenetic patterns that have so far been assumed to reflect clonal relationships, in fact reflect variation in recombination rates across lineages.
    1. Evolutionary Biology

    Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes

    Katelyn Mika, Mirna Marinić ... Vincent J Lynch
    Comparative studies of gene expression in the uterus during pregnancy identifies new genes important for pregnancy and associated with complications such as preterm birth.
    1. Stem Cells and Regenerative Medicine

    Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

    Joseph Herdy, Simon Schafer ... Fred H Gage
    An unbiased RNAseq based strategy to identify targetable pathways and a streamlined lentiviral system provide a state of the art advance on direct fibroblast to neuron conversion.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci

    Reza K Hammond, Matthew C Pahl ... Struan FA Grant
    By integrating GWAS data sets with ATAC-seq and promoter-focused Capture C data, one can uncover further loci beyond those that reach genome-wide significance (p<5x10-8).
    1. Neuroscience

    Impact of blindness onset on the representation of sound categories in occipital and temporal cortices

    Stefania Mattioni, Mohamed Rezk ... Olivier Collignon
    Early and late visual deprivation trigger a redeployment mechanism that reallocate part of the processing typically tagging the preserved senses (i.e. the temporal cortex for auditory stimulation) to the occipital cortex deprived of its most salient visual input.
    1. Genetics and Genomics
    2. Neuroscience

    Temporal transcriptomics suggest that twin-peaking genes reset the clock

    William G Pembroke, Arran Babbs ... Peter L Oliver
    RNA sequencing reveals the finer details of circadian variation in the mammalian master pacemaker over 24 hours, which suggests that transcriptional timing influences clock resetting mechanisms.
    1. Neuroscience

    Corticofugal regulation of predictive coding

    Alexandria MH Lesicko, Christopher F Angeloni ... Maria N Geffen
    A specific neuronal pathway within the auditory system represents information about the statistical prediction and error for incoming sounds, thereby contributing to efficient representation of complex sounds and sound streams in the brain.
    1. Neuroscience

    Control of adaptive action selection by secondary motor cortex during flexible visual categorization

    Tian-Yi Wang, Jing Liu, Haishan Yao
    The secondary motor cortex causally contributes to flexible action selection during stimulus categorization with the representations of upcoming choice and sensory history regulated by the demand to remap stimulus–action association.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations

    Annamarie E Bustion, Renuka R Nayak ... Katherine S Pollard
    Computational reaction representations and profile hidden Markov model searches of metagenomics databases can be harnessed to accurately predict bacterial species and enzyme sequences responsible for biotransformations in the human gut microbiome.

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