The hypoxia-inducible factor HIF drives transcription of the gene cyp-36A1, which encodes a cytochrome P450 enzyme that acts via a putative intercellular signal to regulate the nuclear receptor NHR-46 and consequently stress resistance and behavior.

Besides a cell autonomous role in regulating proliferation, YAP regulates the production of several extracellular molecules allowing for population-level coordination of cell growth and death.

Loss of full-length dystrophin expression causes significant molecular and functional defects in human and mouse myoblast, thus closing the vicious cycle of DMD pathology.

In mouse models of Rett syndrome, the impaired cell autonomous BDNF feed forward signaling pathway results in abnormalities in neurite outgrowth and synapse formation in excitatory neurons.

The temporal patterns of MAPK activity differentially regulate cell autonomous and non-cell autonomous effects of oncogene expression.

Ptch1/2 can lower the sensitivity of Smo to activation by Shh via the secretion of a sterol precursor.

A novel genetic strategy for induction of reproducible neural tumors (or any other deleterious phenotype) in a single Drosophila stock (applicable to other organisms).

Galectin-9 directly binds to arabinogalactan (AG), leading to the identification of AG-specific monoclonal antibodies that effectively inhibit Mycobacterium tuberculosis growth, providing insights for novel tuberculosis therapies.

Expression of almost half of a library of fluorescent reporters distinguish long- from short-lived individual Caenorhabditis elegans, suggesting that organism-wide differences in gene expression drive future lifespan.

Localized lignin impregnations, forming a pan-endodermal net-like diffusion barrier strongly relies on stabilizing signals from neighbors.