3,209 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells

    Despoina Mademtzoglou et al.
    Ablation of the Cdkn1c cell cycle inhibitor leads to defective muscle stem cell dynamics and myogenic potential, while progressive cytoplasmic to nuclear cellular localization of the Cdkn1c protein regulates growth arrest.
    1. Cell Biology
    2. Computational and Systems Biology

    Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity

    Miriam Bracha Ginzberg et al.
    Cells employ two strategies, adjusting both their cell cycle lengths and their growth rates in a size-dependent manner, to correct aberrations in cell size.
    1. Cell Biology

    An extensive program of periodic alternative splicing linked to cell cycle progression

    Daniel Dominguez et al.
    Extensive periodic regulation of alternative splicing during the cell cycle in genes is linked to cell cycle functions, and involves an auto-inhibitory mechanism that uses the protein kinase CLK1.
    1. Cell Biology

    CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets

    Jordina Guillén-Boixet et al.
    CPEB4's switch from translational repressor to activator is regulated during cell cycle by hyperphosphorylation of its intrinsically disordered domain, which controls its phase-separation into RNA-containing liquid-like droplets.
    1. Cell Biology

    The vacuole/lysosome is required for cell-cycle progression

    Yui Jin, Lois S Weisman
    The endo-lysosomal system plays a positive essential role in the initiation of the cell cycle in yeast.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Histone supply regulates S phase timing and cell cycle progression

    Ufuk Günesdogan et al.
    Controlling cell cycle progression in a developing embryo directly depends on de novo histone supply and a specialized surveillance mechanism for nucleosome assembly.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteomic analysis of the response to cell cycle arrests in human myeloid leukemia cells

    Tony Ly et al.
    Building on previous work (Ly et al., 2014), we show that elutriated cells and arrested cells have similar patterns of DNA content and cyclin expression: however, a large fraction of the proteome changes detected in arrested cells are found to reflect arrest-specific responses rather than physiological cell cycle regulation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells

    Jihoon Shin et al.
    The regulation of the core transcription factor Oct4 by the Aurkb-PP1 axis links the cell cycle to pluripotency programs in embryonic stem cells.
    1. Microbiology and Infectious Disease

    Cell cycle constraints on capsulation and bacteriophage susceptibility

    Silvia Ardissone et al.
    A multi-layered and conserved cell cycle mechanism prevents capsulation, long known as a bacterial virulence determinant, in G1-phase and concurrently licenses bacteriophage-mediated genetic exchange prior to entry into S-phase.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells

    Tony Ly et al.
    Quantitative analysis of protein and mRNA expression across a minimally perturbed cell cycle in human myeloid cells has identified myeloid-specific and cell cycle-regulated gene expression, including examples of isoform- and phosphorylation-specific regulation, with all data made available in a searchable, online database.

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