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    1. Developmental Biology

    Extensive and diverse patterns of cell death sculpt neural networks in insects

    Sinziana Pop et al.
    Developmental cell death plays a key role during insect neurogenesis and is increased in specific neuronal populations in flies that have evolved flightlessness.
    1. Cell Biology

    Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

    Jason Karch et al.
    The proteins Bax and Bak, which increase the permeability of the mitochondrial membrane during apoptosis, are also crucial for generating a mitochondrial membrane pore that is specifically involved in necrosis.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

    Laura E Sanman et al.
    A signal for inflammatory cell death is induced by the disruption of cellular metabolism.
    1. Developmental Biology
    2. Neuroscience

    Clustered gamma-protocadherins regulate cortical interneuron programmed cell death

    Walter R Mancia Leon et al.
    Pcdhg determine survival of the GABAergic cortical interneuron population that is necessary to establish and maintain proper excitatory to inhibitory balance in the cerebral cortex.
    1. Developmental Biology

    Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway

    Ainhoa Pérez-Garijo et al.
    A common mechanism might regulate the communal death of cells in flies and mammals.
    1. Cell Biology
    2. Immunology and Inflammation

    A role for phagocytosis in inducing cell death during thymocyte negative selection

    Nadia S Kurd et al.
    Self-reactive thymocyte death is most efficient when peptide-presenting cells are phagocytic, and blocking phagocytosis inhibits self-reactive thymocyte death, suggesting that phagocytes play central roles during thymocyte negative selection.
    1. Neuroscience

    SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration

    Yo Sasaki et al.
    A mouse model of retinal degeneration reveals a common mechanism for axonal degeneration and photoreceptor cell death and identifies SARM1 as a therapeutic candidate for retinopathies.
    1. Cell Biology

    Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death

    Marta Bogacz, R Luise Krauth-Siegel
    Ferroptosis is an evolutionary ancient process that is counterbalanced by distant peroxidases, GPx4 in mammals and tryparedoxin peroxidases in trypanosomes, and can be induced at distinct subcellular membranes depending on the individual cell type.
    1. Cell Biology
    2. Evolutionary Biology

    The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death

    Nicole L Nuckolls et al.
    The Wtf4 antidote protein assembles with the Wtf4 poison protein and promotes the transportation of the assembled proteins to the vacuole for sequestration or destruction.
    1. Cancer Biology
    2. Cell Biology

    Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

    William Putzbach et al.
    Loading of CD95 and CD95L-derived sequences into the RNA-induced silencing complex elicits a distinct form of RNAi-mediated cell death of cancer cells that results from the targeting of multiple survival genes.