3,609 results found
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development

    Wenwen Zhou et al.
    The conserved mechanism of Notch down-regulation by endo-lysosomal trafficking plays important roles in the proliferation and differentiation of stem and progenitor cells during embryogenesis or organogenesis in vertebrates.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development

    Jaeyoung Shin et al.
    Genetic and biochemical approaches identify a new component of the cellular signaling machinery driving migration of limb muscle precursor cells during mouse embryogenesis and reveal the underlying molecular mechanism.
    1. Developmental Biology and Stem Cells
    2. Microbiology and Infectious Disease

    A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development

    Jennifer Hampton Hill et al.
    A previously undescribed protein produced by certain resident intestinal bacteria induces zebrafish pancreatic beta cell expansion.
    1. Developmental Biology and Stem Cells
    2. Immunology and Inflammation

    The NFκB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing γδ T cells

    Florian Mair et al.
    Thymic stromal cells help to develop and shape the gamma delta T cell pool.
    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    Discovering sparse transcription factor codes for cell states and state transitions during development

    Leon A Furchtgott et al.
    Sparse patterns in gene expression allow simultaneous discovery of cell states, lineage relationships and key genes controlling developmental decisions.
    1. Developmental Biology and Stem Cells

    Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development

    Max van Lessen et al.
    The discovery of a unique brain lymphatic cell type in the zebrafish model will facilitate the study of embryonic development and physiology, an essential mission to understand how clearance of macromolecules impact neurological diseases.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans

    Maxime J Kinet et al.
    A pathway controlling non-apoptotic developmental cell death engages non-canonical death-promoting activities of the stress factor HSF-1, which, in turn, activates specific components of the ubiquitin-mediated degradation machinery.
    1. Developmental Biology and Stem Cells
    2. Immunology and Inflammation

    The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor

    Xiaofei Yu et al.
    The transcription factor NFIL3 is essential for the development of a committed bone marrow precursor that gives rise to all known innate lymphoid cell lineages in mice.
    1. Developmental Biology and Stem Cells
    2. Human Biology and Medicine

    Organ Development: Tips from the embryonic lung

    Avinash Waghray, Jayaraj Rajagopal
    A new source of progenitor cells can now be used to study hidden aspects of human lung development and pediatric lung disease.
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    1. Developmental Biology and Stem Cells
    2. Human Biology and Medicine

    Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

    Marko Z Nikolić et al.
    Improved characterisation of human embryonic lung development highlights human-mouse differences and facilitates the development of defined culture conditions for the expansion of self-renewing, multipotent human lung epithelial progenitor cells.

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