9,804 results found
    1. Computational and Systems Biology

    Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

    Fuqing Wu et al.
    A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.
    1. Developmental Biology
    2. Plant Biology

    Control of plant cell fate transitions by transcriptional and hormonal signals

    Christophe Gaillochet et al.
    HEC transcription factors control the timing of cell fate transitions in a dynamic stem cell system, allowing plants to adapt their developmental program to diverse environments.
    1. Neuroscience

    Firing rate-dependent phase responses of Purkinje cells support transient oscillations

    Yunliang Zang et al.
    Computational and theoretical models show that rate adaptation of phase responses can regulate Purkinje cell outputs by forming transient oscillations in fast-spiking neurons.
    1. Developmental Biology
    2. Genetics and Genomics

    OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification

    Miruna Georgiana Ghinia Tegla et al.
    A retinal gene regulatory network prevents the formation of alternative cell fates from non-stochastic retinal progenitor cells.
    1. Cell Biology
    2. Developmental Biology

    Tgfβ signaling is critical for maintenance of the tendon cell fate

    Guak-Kim Tan et al.
    Conditional deletion of TGFβ signaling results in tenocyte dedifferentiation in vivo demonstrating a key role for TGFβ signaling in the maintenance of the tendon cell fate.
    1. Developmental Biology

    Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

    Néstor Saiz et al.
    A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
    1. Developmental Biology
    2. Plant Biology

    Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium

    Elvira Hernandez-Lagana et al.
    In the Arabidopsis ovule primordium, germinal fate plasticity is coupled to the morphogenetic processes shaping the organ.
    1. Developmental Biology

    A switch in transcription and cell fate governs the onset of an epigenetically-deregulated tumor in Drosophila

    Joana Torres et al.
    A previously unknown oncogenic feature of an embryonic transcription factor was uncovered from transcriptomic analysis of tumors that lack functional Polycomb silencing.
    1. Developmental Biology
    2. Cancer Biology

    RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells

    Maaike PA van Bragt et al.
    Loss of RUNX1, a key regulator of estrogen receptor-positive luminal breast cells, impairs mammary epithelial differentiation and contributes to luminal breast cancer via genetic interactions with a loss of p53 or RB1.
    1. Developmental Biology

    Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

    Shiri Kult et al.
    The molecular identity of bi-fated tendon-to-bone attachment cells, which display a mixture of transcriptomes of two neighboring cell types, enables the formation of the unique transitional tissue of the enthesis.

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