In contrast to previous post-mortem or fixed tissue histochemical reports, live calcium and mitochondrial imaging data suggest that the enteric nervous system is not generally affected in Parkinson's disease patients.
NusG enhances transcription elongation by stabilizing DNA base pairs immediately upstream of the RNA-DNA hybrid but does not measurably affect the nucleotide incorporation and the forward translocation by RNA polymerase.
Nhat TD Nguyen, Ashutosh K Pathak, Isabella M Cattadori
Helminth infected hosts are an important cause of variation in the level, frequency and duration of Bordetella bronchiseptica shedding and dynamics of infection.
Nicholas O Burton, Alexandra Willis ... Eric A Miska
Intergenerational adaptations to stress play a critical role in organismal responses to changing environments and are largely lost or erased after one generation.
Early and late visual deprivation trigger a redeployment mechanism that reallocate part of the processing typically tagging the preserved senses (i.e. the temporal cortex for auditory stimulation) to the occipital cortex deprived of its most salient visual input.
Phototaxis and courtship behavioral preferences reflect strong correlation with differences in olfactory and visual nervous system investment across five monophyletic Drosophila species, and could help explain their speciation events.
Rupinder Sayal, Jacqueline M Dresch ... David N Arnosti
Mathematical modeling of mutagenesis data for a suite of enhancers uncovers new relationships between the binding sites of transcription factors that help in genome-wide prediction of enhancers.
A deep mutational coupling study demonstrates the ability of sequence coevolution methods to reveal the pattern of amino acid interactions underlying protein function.
Bulk whole genome sequencing data can be used to study the genetic variation present in pathogenic bacterial populations over the time-course of a single infection within a host.
