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    1. Cell Biology

    Modeling single-cell phenotypes links yeast stress acclimation to transcriptional repression and pre-stress cellular states

    Andrew C Bergen, Rachel A Kocik ... Audrey P Gasch
    Counterintuitively, activation of the transcriptional repressor of growth-promoting genes is important for yeast cell acclimation to salt stress, such that cells with larger activation of the repressor tend to have faster growth acclimation after stress.
    1. Evolutionary Biology

    Tradeoff breaking as a model of evolutionary transitions in individuality and limits of the fitness-decoupling metaphor

    Pierrick Bourrat, Guilhem Doulcier ... Katrin Hammerschmidt
    A new model describes evolutionary transitions in individuality in terms of tradeoff and tradeoff-breaking events as opposed to changes in the nature of fitness.
    1. Microbiology and Infectious Disease

    Cooperation between distinct viral variants promotes growth of H3N2 influenza in cell culture

    Katherine S Xue, Kathryn A Hooper ... Jesse D Bloom
    The frequent co-occurrence of two variants of influenza is due to the fact that they cooperate, meaning that a mixed population grows better than either variant alone.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Experimental evolution for the recovery of growth loss due to genome reduction

    Kenya Hitomi, Yoichiro Ishii, Bei-Wen Ying
    Diversified genetic and transcriptional changes in parallel evolved Escherichia coli populations for improved growth revealed that the evolution complementing genome reduction was like all roads leading to Rome.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host–pathogen dynamics in lymphoblastoid cell lines

    Elliott D SoRelle, Joanne Dai ... Micah A Luftig
    Single-cell RNA sequencing highlights the influence of host–pathogen interactions and stochasticity on transcriptional and phenotypic variance in lymphoblastoid cell lines derived from Epstein–Barr virus-infected primary B cells.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Bacterial survival in microscopic surface wetness

    Maor Grinberg, Tomer Orevi ... Nadav Kashtan
    A new intricate reciprocity between microbiology and physics results in collective protection from desiccation through differential formation of stable microdroplets around bacterial aggregates on surfaces drying under moderate humidity.
    1. Computational and Systems Biology

    Evolution of cell size control is canalized towards adders or sizers by cell cycle structure and selective pressures

    Felix Proulx-Giraldeau, Jan M Skotheim, Paul François
    An evolutionary algorithm is used to build gene networks implementing cell size control, and suggests multiple ways for evolution to first build sizers and turn them into adders depending on evolutionary constraints.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic tuning of gene expression enables cellular adaptation in the absence of pre-existing regulatory circuitry

    Lydia Freddolino, Jamie Yang ... Saeed Tavazoie
    Stochastic tuning of gene expression could be a common mechanism through which eukaryotic cells adapt to challenging external environments, potentially including survival of infectious organisms within the host and adaptation of cancer cells to chemotherapy.
    1. Cell Biology

    Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans

    Chia-An Yen, Dana L Ruter ... Sean P Curran
    Loss of FAD stemming from cell autonomous defects in mitochondrial proline catabolism impairs sperm quality male reproductive advantage in C. elegans.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

    Patrick T Dolan, Shuhei Taguwa ... Judith Frydman
    Distinct selective landscapes in mosquito and human cells shape dengue virus genetic diversity and highlight mechanisms of host adaptation in arboviruses.