10,304 results found
    1. Chromosomes and Gene Expression

    The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells

    Adrien Georges et al.
    FOXL2 maintenance of ovarian identity is not solely due to a simple direct repression of Sox9 but to the mobilization of estrogen signalling by FOXL2.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq

    Dylan Kotliar et al.
    A novel algorithm, consensus non-negative matrix factorization (cNMF), accurately identifies gene expression programs underlying cell-type identity and cellular activities from single-cell RNA-Seq data.
    1. Cell Biology
    2. Physics of Living Systems

    Variations of intracellular density during the cell cycle arise from tip-growth regulation in fission yeast

    Pascal D Odermatt et al.
    The density of the cytoplasm in S. pombe varies in time and space during the cell cycle through modulation of tip growth rate coupled with constant mass growth rate.
    1. Stem Cells and Regenerative Medicine

    Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes

    Noemi Rives-Quinto et al.
    Silencing of stem cell identity genes during progenitor commitment ensures that intermediate progenitors robustly commit to generate differentiated cell types rather than abnormal stem-cell-like cells during indirect neurogenesis.
    1. Cell Biology

    The transcription factor Hey and nuclear lamins specify and maintain cell identity

    Naama Flint Brodsly et al.
    Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.
    1. Cancer Biology

    Arid1a restrains Kras-dependent changes in acinar cell identity

    Geulah Livshits et al.
    Arid1a loss in the pancreas enables an irreversible reprogramming of cell fate that is dependent on both cellular and genetic context.
    1. Cell Biology
    2. Developmental Biology

    Plasticity of both planar cell polarity and cell identity during the development of Drosophila

    Pedro Saavedra et al.
    In the Drosophila larval epidermis both the cell identity and polarity of individual cells change as a result of cell rearrangements.
    1. Cell Biology
    2. Developmental Biology

    A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging

    Neta Erez et al.
    A nuclear Non-stop identity complex (NIC) supervises enterocyte (EC) identity, preserves tissue homeostasis, and prevents premature aging by maintaining EC-specific gene expression, silencing non-relevant programs, and safeguarding large-scale nuclear organization.
    1. Developmental Biology
    2. Neuroscience

    Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

    Ya-Ping Yen et al.
    LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.
    1. Chromosomes and Gene Expression

    Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

    Nina Kirstein et al.
    Replication origins are established throughout the genome with the exception of transcribed genes, and the local chromatin composition likely modulates the density of ORC and MCM as well as origin activation.

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