8,956 results found
    1. Chromosomes and Gene Expression

    The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells

    Adrien Georges et al.
    FOXL2 maintenance of ovarian identity is not solely due to a simple direct repression of Sox9 but to the mobilization of estrogen signalling by FOXL2.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq

    Dylan Kotliar et al.
    A novel algorithm, consensus non-negative matrix factorization (cNMF), accurately identifies gene expression programs underlying cell-type identity and cellular activities from single-cell RNA-Seq data.
    1. Stem Cells and Regenerative Medicine

    Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes

    Noemi Rives-Quinto et al.
    Silencing of stem cell identity genes during progenitor commitment ensures that intermediate progenitors robustly commit to generate differentiated cell types rather than abnormal stem-cell-like cells during indirect neurogenesis.
    1. Cell Biology

    The transcription factor Hey and nuclear lamins specify and maintain cell identity

    Naama Flint Brodsly et al.
    Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.
    1. Cancer Biology

    Arid1a restrains Kras-dependent changes in acinar cell identity

    Geulah Livshits et al.
    Arid1a loss in the pancreas enables an irreversible reprogramming of cell fate that is dependent on both cellular and genetic context.
    1. Cell Biology
    2. Developmental Biology

    Plasticity of both planar cell polarity and cell identity during the development of Drosophila

    Pedro Saavedra et al.
    In the Drosophila larval epidermis both the cell identity and polarity of individual cells change as a result of cell rearrangements.
    1. Developmental Biology
    2. Neuroscience

    Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

    Ya-Ping Yen et al.
    LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.
    1. Computational and Systems Biology
    2. Developmental Biology

    Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension

    Robert J Tetley et al.
    Analysing Myosin II unipolar planar polarisation with high spatial and temporal resolution during Drosophila axis extension reveals how tissue boundaries drive polarized cell intercalation while limiting cell mixing.
    1. Neuroscience

    Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs

    Nathan T Henderson et al.
    Competition between neurons for postsynaptic ephrin-B3 controls distribution of a limited pool of synapses and defines a novel trans-synaptic mechanism enabling neurons to set the number of synapses they receive.
    1. Computational and Systems Biology
    2. Developmental Biology

    Universality of clonal dynamics poses fundamental limits to identify stem cell self-renewal strategies

    Cristina Parigini, Philip Greulich
    Stem cell self-renewal strategies fall into two classes, and only strategies of different classes can be experimentally distinguished via static clonal data.

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