Transgenic mice with high levels of FGF21 live for longer than wild-type mice and do so without reducing food intake.

A unique form of regulation has been observed in the unfolded protein response of S. pombe, along with a novel mechanism of post-transcriptional mRNA processing.

The development of colonies of cells in choanoflagellates, water-dwelling organisms that feed on bacteria, is triggered by the presence of very low concentrations of a lipid molecule produced by certain types of bacteria.

Cauliflower mosaic virus reacts immediately when aphids feed on the host plant, and this boosts its chances of being taken up and transmitted by the insects to a new plant.

Sensory neurons in the olfactory system develop from two different regions of the ectoderm, the olfactory placode and the cranial neural crest, whereas sensory neurons within the eye and ear develop from just one region.

By using different groups of cells to represent distinct environments and events, the dentate gyrus of the hippocampus helps to keep memories of similar events separate.

The ability to share resources for the benefit of all members of a group may have driven ancient organisms to evolve from a unicellular to a multicellular state.

COPII vesicles regulate the metabolism of cholesterol through the selective transport of secretory proteins.

Mutagenesis studies identified an androgen receptor mutation that converts enzalutamide-a drug recently approved for the treatment of advanced prostate cancer-into an androgen receptor agonist, and modeling studies informed the design of novel drugs that are effective against the mutant receptor.

A combination of detailed sampling and mathematical modeling suggests that the response of immune cells to reactivation of herpes simplex virus 2 is extremely rapid and effective within microscopic areas of genital skin.