Transgenic mice with high levels of FGF21 live for longer than wild-type mice and do so without reducing food intake.

A unique form of regulation has been observed in the unfolded protein response of S. pombe, along with a novel mechanism of post-transcriptional mRNA processing.

The development of colonies of cells in choanoflagellates, water-dwelling organisms that feed on bacteria, is triggered by the presence of very low concentrations of a lipid molecule produced by certain types of bacteria.

Electron microscopy has been used to produce the first three-dimensional image of the PRC2 gene-silencing complex.

Intramembrane proteases identify target proteins in a different way from other proteases.

Biochemical and genetic tests have revealed that a liver protein called NTCP is a functional receptor for hepatitis B and D viruses, which should lead to an improved understanding of the infections caused by these viruses and assist the development of new intervention strategies.

Histones bound to lipid droplets inside cells offer protection against bacteria in flies, and possibly mice, thus suggesting a possible new innate immunity pathway.

The transcription machinery used to regulate gene expression and self-renewal in human embryonic stem cells is different from that found in other cells.

A chromatin boundary factor that is only active during early embryo development has been discovered in Drosophila.