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Page 3 of 1,194
    1. Biochemistry and Chemical Biology

    A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking

    Katherine J Susa, Tom CM Seegar ... Andrew C Kruse
    The tetraspanin CD81 uses its ectodomain to export CD19, and the interaction of the two proteins is dynamically regulated by B cell activation state.
    1. Microbiology and Infectious Disease

    Differential interaction forces govern bacterial sorting in early biofilms

    Enno R Oldewurtel, Nadzeya Kouzel ... Berenike Maier
    Differential physical interactions between bacteria in mixed microcolonies trigger cell sorting.
    1. Developmental Biology

    Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord

    Héctor Sánchez-Iranzo, Aliaksandr Halavatyi, Alba Diz-Muñoz
    Interaction strength in Notch signaling determines lateral inhibition patterning and drives fate in the unidimensional cell arrangement of the zebrafish notochord.
    1. Immunology and Inflammation

    Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity

    Marianne Burbage, Francesca Gasparrini ... Facundo D Batista
    Intersectin2 deficiency is associated with impaired humoral responses to viral infection and B-cell-intrisic defects in germinal centre formation, resulting from the reduced ability of intersectin2-KO B cells to establish cognate interactions with helper T cells.
    1. Developmental Biology

    A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

    Qiuyu Guo, Albert Kim ... Andrew P McMahon
    β-Catenin-mediated expansion of nephron progenitors is independent of direct β-catenin/chromatin engagement, while progenitor induction proceeds with a β-catenin-driven switch of repressive TCFL1/TCFL2 to activating TCF7/LEF1 factors on transcriptionally poised enhancers.
    1. Cell Biology
    2. Immunology and Inflammation

    A two-hybrid antibody micropattern assay reveals specific in cis interactions of MHC I heavy chains at the cell surface

    Cindy Dirscherl, Zeynep Hein ... Sebastian Springer
    A generally applicable two-hybrid assay demonstrates that MHC class I heavy chains devoid of beta-2 microglobulin associate within and across allotypes, with implications for endocytosis and autoimmunity.
    1. Cell Biology
    2. Cancer Biology

    Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion

    Elena Tomas Bort, Megan D Joseph ... Richard P Grose
    New role of P2Y2-αV integrin interactions in ATP-driven pancreatic cancer cell invasion provides a potential anti-metastatic target for pancreatic cancer.
    1. Cancer Biology
    2. Cell Biology

    EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells

    Benjamin Krusche, Cristina Ottone ... Simona Parrinello
    EphrinB2 promotes glioblastoma stem-like cell malignancy through the interplay of cell-autonomous and non-cell-autonomous mechanisms and its targeting suppresses tumourigenesis in preclinical models of human glioblastoma.
    1. Physics of Living Systems

    Interplay of surface interaction and magnetic torque in single-cell motion of magnetotactic bacteria in microfluidic confinement

    Agnese Codutti, Mohammad A Charsooghi ... Stefan Klumpp
    Confined magnetotactic bacteria exhibit circling and U-turn trajectories explained by a competition of alignment with a magnetic field and alignment along the confining walls as well as considerable cell-to-cell heterogeneity.
    1. Cell Biology
    2. Developmental Biology

    An in vitro stem cell model of human epiblast and yolk sac interaction

    Kirsty ML Mackinlay, Bailey AT Weatherbee ... Magdalena Zernicka-Goetz
    Human yolk sac-like cells, which share characteristics with the post-implantation human hypoblast, can model the interaction between the epiblast and hypoblast that occurs during early human development.