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    1. Epidemiology and Global Health

    Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites

    Qianxi Feng, Eric Nickels ... Joseph L Wiemels
    Familial cancer clustering was significantly higher in US minority populations compared to those of US European origin, suggesting renewed need for a focus on family cancer predisposition in US Latinos, Blacks, and Asian/Pacific Islanders.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural insight into the dual function of LbpB in mediating Neisserial pathogenesis

    Ravi Yadav, Srinivas Govindan ... Nicholas Noinaj
    Structural and biophysical studies detail how Neisseria LbpB interacts with human lactoferrin for iron piracy and provides insight for how LbpB interacts with the antimicrobial peptide lactoferricin.
    1. Neuroscience

    Emotional faces guide the eyes in the absence of awareness

    Petra Vetter, Stephanie Badde ... Marisa Carrasco
    When emotional faces are rendered invisible, our eyes look towards fearful faces and away from angry faces.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of a bacterial ATP synthase

    Hui Guo, Toshiharu Suzuki, John L Rubinstein
    Construction of a first atomic model for an intact bacterial ATP synthase allows for a structural understanding of the roles of individual amino acids in the mechanism of ATP synthesis.
    1. Neuroscience

    Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment

    Yanan Chen, Rejani B Kunjamma ... Brian Popko
    Oligodendrocytes with an enhanced ability to withstand cytotoxic stress display an increased capacity to remyelinate demyelination lesions of the CNS in the presence of an inflammatory environment.
    1. Neuroscience

    Drosophila gustatory projections are segregated by taste modality and connectivity

    Stefanie Engert, Gabriella R Sterne ... Kristin Scott
    Anatomical and synaptic reconstructions of gustatory axons from the adult Drosophila labellum reveal different classes of gustatory neurons recognizing different taste modalities.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    The accessory helix of complexin functions by stabilizing central helix secondary structure

    Daniel T Radoff, Yongming Dong ... Jeremy S Dittman
    A deeply conserved feature of complexin's secondary structure underlies its inhibitory function despite poor primary sequence conservation.
    1. Neuroscience

    Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation

    Zuzanna Brzosko, Sara Zannone ... Ole Paulsen
    Sequential neuromodulation by acetylcholine and dopamine enables correlational synaptic learning which, when incorporated into a computational model, yields effective navigation toward changing reward locations as in natural foraging behavior.
    1. Neuroscience

    Neural signatures of perceptual inference

    William Sedley, Phillip E Gander ... Timothy D Griffiths
    Changes to sensory predictions are encoded by beta oscillations, surprise due to prediction violations by gamma oscillations, and alpha oscillations may have a role in controlling the precision of predictions.
    1. Computational and Systems Biology
    2. Neuroscience

    Prediction of primary somatosensory neuron activity during active tactile exploration

    Dario Campagner, Mathew Hywel Evans ... Rasmus Strange Petersen
    Primary trigeminal neurons encode rotational forces in awake mice as they explore an object with their whiskers, allowing accurate prediction of spiking during behaviour.