Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
A multi-scale integration of experimental and computational approaches shows how a non-linear dependence of T-type calcium channel gating on GABAB receptor activity regulates thalamic network oscillations.
The employment of xenopsin in ciliary and mixed microvillar/ciliary eye sensory cells in several protostome animals suggests high evolutionary plasticity of photoreceptors.
A stepped-wedge randomised controlled trial shows that early antiretroviral therapy (ART) initiation does not negatively affect the economic welfare of HIV patients in a low-income country.
Single-cell analyses identify distinct epithelial populations that are conserved between the adult mouse and human prostate, including populations with properties of multipotent progenitors in organoid formation and tissue reconstitution assays.
Unbiased analyses highlight context-specific crosstalk between Notch, DNA damage response genes, and PP2A, and provide a roadmap for understanding how Notch induces squamous cell differentiation.
Selective APC/C-mediated proteolysis of cyclin B drives progression through the metaphase-anaphase transition whilst wide-spread waves of dephosphorylation co-ordinate the subsequent events of mitotic exit.
The release of acetylcholine in the basolateral amygdala is precisely timed to salient events during reward learning but has long-lasting effects that potentiate learning of cue-reward contingencies.
Cell-type-specific ribosome profiling during prion disease progression identified minor translational changes in neurons as well as profound glia changes many of which are shared with other neurodegenerative diseases.
