5,413 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

    Sumeda Nandadasa et al.
    Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
    1. Computational and Systems Biology
    2. Neuroscience

    Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations

    Adam C Lu et al.
    A multi-scale integration of experimental and computational approaches shows how a non-linear dependence of T-type calcium channel gating on GABAB receptor activity regulates thalamic network oscillations.
    1. Evolutionary Biology
    2. Neuroscience

    The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution

    Clemens Christoph Döring et al.
    The employment of xenopsin in ciliary and mixed microvillar/ciliary eye sensory cells in several protostome animals suggests high evolutionary plasticity of photoreceptors.
    1. Neuroscience

    Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease

    Henri Leinonen et al.
    Mouse retina manifests homeostatic plasticity and adapts to photoreceptor degeneration to resist visual decline.
    1. Epidemiology and Global Health
    2. Medicine

    A stepped-wedge randomised trial on the impact of early ART initiation on HIV-patients’ economic outcomes in Eswatini

    Janina Isabel Steinert et al.
    A stepped-wedge randomised controlled trial shows that early antiretroviral therapy (ART) initiation does not negatively affect the economic welfare of HIV patients in a low-income country.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

    Laura Crowley et al.
    Single-cell analyses identify distinct epithelial populations that are conserved between the adult mouse and human prostate, including populations with properties of multipotent progenitors in organoid formation and tissue reconstitution assays.
    1. Cancer Biology
    2. Cell Biology

    IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation

    Li Pan et al.
    Unbiased analyses highlight context-specific crosstalk between Notch, DNA damage response genes, and PP2A, and provide a roadmap for understanding how Notch induces squamous cell differentiation.
    1. Cell Biology

    Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit

    James Holder et al.
    Selective APC/C-mediated proteolysis of cyclin B drives progression through the metaphase-anaphase transition whilst wide-spread waves of dephosphorylation co-ordinate the subsequent events of mitotic exit.
    1. Neuroscience

    Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency

    Richard B Crouse et al.
    The release of acetylcholine in the basolateral amygdala is precisely timed to salient events during reward learning but has long-lasting effects that potentiate learning of cue-reward contingencies.
    1. Neuroscience

    Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons

    Claudia Scheckel et al.
    Cell-type-specific ribosome profiling during prion disease progression identified minor translational changes in neurons as well as profound glia changes many of which are shared with other neurodegenerative diseases.

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