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    1. Immunology and Inflammation

    Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

    Dorothy K Sojka et al.
    Natural killer cells that were commonly thought to circulate around the body can actually reside in distinct tissues, such as in the liver, skin or uterus, and do not re-circulate.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Polycomb enables primitive endoderm lineage priming in embryonic stem cells

    Robert S Illingworth et al.
    Polycomb enables lineage priming in mouse embryonic stem cells by establishing a barrier to commitment.
    1. Cancer Biology

    Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging

    Takahisa Maruno et al.
    Genetic lineage tracing approach combined with live imaging visualized the functional stem cell activity of Doublecortin-like kinase 1+ cells within pancreatic cancer in vivo.
    1. Cell Biology
    2. Developmental Biology

    Cell lineage and cell cycling analyses of the 4d micromere using live imaging in the marine annelid Platynereis dumerilii

    B Duygu Özpolat et al.
    Lineage tracing at single-cell resolution reveals the presence of mesoteloblasts, the embryonic origin of mesodermal growth zone cells, and diverse cell cycling patterns of these lineages in the 'Polychaete' annelid Platynereis.
    1. Developmental Biology

    Multi-view light-sheet imaging and tracking with the MaMuT software reveals the cell lineage of a direct developing arthropod limb

    Carsten Wolff et al.
    Quantitative analyses of multi-dimensional microscopy datasets with a new Fiji/ImageJ plugin for cell tracking reveal the lineage restrictions and morphogenetic cellular behaviors underlying embryonic limb outgrowth in the direct developing crustacean Parhyale hawaiensis.
    1. Immunology and Inflammation

    HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4+CD8+ thymocytes for CD4-lineage commitment

    Rachael Laura Philips et al.
    CD4 lineage commitment requires HDAC3 to prevent premature upregulation of CD8 lineage genes during T cell development.
    1. Developmental Biology

    Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

    Néstor Saiz et al.
    A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
    1. Stem Cells and Regenerative Medicine

    A mex3 homolog is required for differentiation during planarian stem cell lineage development

    Shu Jun Zhu et al.
    The planarian mex3-1 gene is required for non-stem cell fates and suppresses a stem cell fate in differentiating cells.
    1. Developmental Biology

    An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution

    Aubrey GA Howard IV et al.
    Single-cell dissection of recent neural crest derivatives in the vertebrate zebrafish reveals diverse transcriptomic signatures among differentiating posterior cell types during the embryonic to larval stage transition.
    1. Developmental Biology

    Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo

    Eszter Posfai et al.
    Lineage specification and commitment are synchronized in the developing trophectoderm lineage of the mouse embryo, but are asynchronous events in the maturing inner cell mass, revealing a window of plasticity in this lineage.