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    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

    Judith Schütte et al.
    A computer model built on insights gained from comprehensive experimental analysis reveals mechanisms of blood stem cell regulation.
    1. Cell Biology
    2. Neuroscience

    Piezo1 links mechanical forces to red blood cell volume

    Stuart M Cahalan et al.
    In red blood cells, the Piezo1 protein is responsible for sensing mechanical forces and volume regulation.
    1. Plant Biology

    Anisotropic growth is achieved through the additive mechanical effect of material anisotropy and elastic asymmetry

    Firas Bou Daher et al.
    Growing upwards in the young seedling is controlled by two cooperative mechanical mechanisms: cellulose orientation in inner tissues and differential elasticity in epidermal cells.
    1. Physics of Living Systems

    Plasticity of cell migration resulting from mechanochemical coupling

    Yuansheng Cao et al.
    Computational and experimental studies show that different migration modes of eukaryotic cells are the result of the interplay between signaling waves and cell mechanics.
    1. Neuroscience
    2. Physics of Living Systems

    The frequency limit of outer hair cell motility measured in vivo

    Anna Vavakou et al.
    The cells in our inner ear commonly believed to provide fast mechanical feedback are too sluggish to follow the vibrations evoked by high-frequency sounds.
    1. Plant Biology

    Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cells

    Benjamin Brandt et al.
    The calcium-dependent signaling pathway during ABA-dependent stomatal closure requires the calcium-independent pathway, and calcium signaling specificity is mediated by PP2C protein phosphatases.
    1. Cancer Biology
    2. Cell Biology

    TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

    Debjani Pal et al.
    Phenotypic diversity and cell state transition (i.e., acquisition of a CD44+/CD24- cell state or exposure to TGF-beta) can spur intra-tumor genetic heterogeneity and contribute to acquired resistance.
    1. Cell Biology
    2. Neuroscience

    Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells

    Matthew J Sternfeld et al.
    Stem cell derived ventral-spinal cord excitatory neurons self-assemble into a rhythmically bursting neural network whose speed and intercellular coordination are both instructively modulated by cell-type specific interactions with inhibitory neurons.
    1. Cancer Biology

    Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells

    Arun M Unni et al.
    Cancer cells driven by mutations in KRAS or EGFR are dependent on DUSP6 to prevent ERK-induced cell death, creating a novel vulnerability for targeted therapy.