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    1. Cell Biology
    2. Developmental Biology

    Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration

    Joana R Carvalho et al.
    Analysis of axial polarity distributions shows that Wnt5a regulates collective cell migration in vivo by stabilizing vinculin at adherens junctions and fine-tuning mechanocoupling between neighbouring cells.
    1. Developmental Biology
    2. Genetics and Genomics

    Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo

    Megan L Martik, David R McClay
    The gene regulatory network controlling directed cell migration in a sea urchin is strikingly similar to a sub-circuit for eye development in Drosophila, suggesting that ancient systems-level controls may be adapted for diverse functions in different animals.
    1. Cell Biology
    2. Computational and Systems Biology

    Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration

    Alfonso Bolado-Carrancio et al.
    Different RhoA and Rac1 dynamics at the cell front and rear are coordinated through periodic GTPase waves, which define the minimal autonomous biochemical machinery necessary and sufficient for cell migration.
    1. Developmental Biology

    The Glide/Gcm fate determinant controls initiation of collective cell migration by regulating Frazzled

    Tripti Gupta et al.
    The role of the Frazzled chemoattractant receptor is to triggers migration initiation as part of the glial developmental program induced by the Glide/Gcm transcription factor.
    1. Developmental Biology

    miR-965 controls cell proliferation and migration during tissue morphogenesis in the Drosophila abdomen

    Pushpa Verma, Stephen M Cohen
    A microRNA-mediated mechanism coordinates cell proliferation with cell rearrangements during tissue morphogenesis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

    Jun Wan et al.
    A new paradigm of DNA methylation mediated gene activation and chromatin remodeling provides a general framework to dissect the biological functions of DNA methylation readers and effectors.
    1. Cell Biology

    ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration

    Joanne Chia et al.
    The ERK8 kinase blocks the export of glycosyl-tranferases from the Golgi to the endoplasmic reticulum, and thus subsequent O-glycosylation of proteins that otherwise enhance cell motility and tissue invasion.
    1. Cell Biology
    2. Physics of Living Systems

    Bridging the gap between single-cell migration and collective dynamics

    Florian Thüroff et al.
    A computational model, based on single-cell features like contractility and polarizability, quantitatively describes cellular dynamics from the single cell level up to small cohorts and confluent tissues.
    1. Developmental Biology

    Pitx2c orchestrates embryonic axis extension via mesendodermal cell migration

    Michelle M Collins et al.
    Expression of Pitx2c at the onset of gastrulation drives convergence and extension movements in the zebrafish embryo by promoting downstream pathways affecting chemokine signaling, integrin-ECM interactions, and planar cell polarity components.
    1. Cell Biology
    2. Developmental Biology

    Ingression-type cell migration drives vegetal endoderm internalisation in the Xenopus gastrula

    Jason WH Wen, Rudolf Winklbauer
    The cellular behaviours that underlie the internalization of the multilayered endoderm anlage in Xenopus laevis link the ancestral mode of vertebrate gastrulation to common, epithelial-based mechanisms of gastrulation in non-vertebrate animals.