Despite ongoing rewiring and continuous turnover of synapses, a computational model shows that memories can maintain and even strengthen their connectivity by self-reactivating during periods without sensory input.
Human yolk sac-like cells, which share characteristics with the post-implantation human hypoblast, can model the interaction between the epiblast and hypoblast that occurs during early human development.
Long-term immune outcomes vary with age, for both adults and children in HIV-infected populations, e.g. long-term scaled carrying capacity is lower in HIV-infected younger individuals compared to older individuals.
Sequential introduction of transcription factors enables large-scale generation of induced motor neurons (iMNs) from human somatic cells, and transplantation of iMNs exhibit therapeutic effects in spinal cord injury model.
Faithful models of RMC require SMARCB1 loss for survival, and genetic and small-molecule screens identify inhibition of the ubiquitin-proteasome system (UPS) as a potential therapeutic approach for SMARCB1 deficient cancers.