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    1. Evolutionary Biology
    2. Genetics and Genomics

    Universal and taxon-specific trends in protein sequences as a function of age

    Jennifer E James, Sara M Willis ... Joanna Masel
    Ancient protein domains remain shaped by amino acid availability during early life, while young animal proteins are shaped by a need for high intrinsic structural disorder.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Structure of the HIV immature lattice allows for essential lattice remodeling within budded virions

    Sikao Guo, Ipsita Saha ... Margaret E Johnson
    Proteins locked into the immature HIV lattice can exploit its incomplete structure to form the essential protease dimer needed for viral maturation.
    1. Neuroscience

    Ripples reflect a spectrum of synchronous spiking activity in human anterior temporal lobe

    Ai Phuong S Tong, Alex P Vaz ... Kareem A Zaghloul
    A continuum of ripple oscillations in human anterior temporal lobe reflects the dynamic synchrony of populations of neurons during memory retrieval.
    1. Neuroscience

    Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses

    Joana S Ferreira, Thomas Papouin ... Laurent Groc
    D-serine has a major role in the regulation of NMDA receptors not only contributing to its activation as the receptors co-agonist, but also by regulating specifically GluN2B-NMDA receptor trafficking and synaptic content at developing hippocampal synapses.
    1. Physics of Living Systems

    Crowding-induced phase separation of nuclear transport receptors in FG nucleoporin assemblies

    Luke K Davis, Ian J Ford, Bart W Hoogenboom
    Computational modelling predicts spatial segregation of different types of nuclear transport receptors in assemblies of nuclear pore proteins, lending support to the idea of separate transport pathways in the nuclear pore complex as a way to enhance transport efficiency.
    1. Genetics and Genomics
    2. Plant Biology

    Stress induced gene expression drives transient DNA methylation changes at adjacent repetitive elements

    David Secco, Chuang Wang ... Ryan Lister
    Phosphate starvation in rice induces widespread, but transient, modulation of DNA methylation near stress responsive genes that is independent from the RNA-directed DNA methylation pathway.
    1. Ecology

    The golden mimicry complex uses a wide spectrum of defence to deter a community of predators

    Stano Pekár, Lenka Petráková ... Marie E Herberstein
    A mimetic complex composed of at least 140 species of ants, wasps, spiders, true bugs and treehoppers, all with conspicuous golden bodies, has been discovered.
    1. Computational and Systems Biology
    2. Neuroscience

    Integrative neuromechanics of crawling in D. melanogaster larvae

    Cengiz Pehlevan, Paolo Paoletti, L Mahadevan
    An integrative model of coordinated crawling in fruit fly maggots links neuromuscular dynamics to body-substrate mechanics in the presence of proprioceptive feedback.
    1. Evolutionary Biology
    2. Neuroscience

    Convergent mosaic brain evolution is associated with the evolution of novel electrosensory systems in teleost fishes

    Erika L Schumacher, Bruce A Carlson
    In teleost fishes, the independent evolution of electrosensory systems was repeatedly associated with evolutionary changes in brain region scaling that were independent of changes in brain–body allometry.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Geminivirus-encoded TrAP suppressor inhibits the histone methyltransferase SUVH4/KYP to counter host defense

    Claudia Castillo-González, Xiuying Liu ... Xiuren Zhang
    A viral protein hijacks the key effector of transcriptional gene silencing, Su(var)3-9, to evade host plant surveillance.