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    1. Computational and Systems Biology

    A network of epigenetic modifiers and DNA repair genes controls tissue-specific copy number alteration preference

    Dina Cramer et al.
    The genetic background of a cancer cell and the chromatin organization of the tissue-of-origin impact the amount, length and position of somatic copy number alterations in cancer.
    1. Developmental Biology and Stem Cells

    Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria

    Carolyn E Adler et al.
    A chemical method has been developed for studying single organ regeneration and fate specification of stem cells in an adult organism.
    1. Developmental Biology and Stem Cells

    Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

    Dorit Hockman et al.
    Embryonic fate-mapping approaches in zebrafish, Xenopus and lamprey illuminate the evolutionary origins of carotid body glomus cells and pulmonary neuroendocrine cells.
    1. Cancer Biology
    2. Developmental Biology and Stem Cells

    Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma

    Inês M Tenente et al.
    MYF5 and MYOD regulate rhabdomyosaroma growth and tumor-propagating potential, acting more than as passive markers retained from the target cell-of-origin during transformation.
    1. Chromosomes and Gene Expression

    Engineered proteins detect spontaneous DNA breakage in human and bacterial cells

    Chandan Shee et al.
    Fluorescent derivatives of a bacteriophage protein that binds double-stranded ends can trap and label genome-destabilizing double-strand DNA breaks in bacterial and human cells, and illuminate the origins of spontaneous DNA breakage in both.
    1. Developmental Biology and Stem Cells

    Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm

    Elliot A Perens et al.
    The Hand2 transcription factor regulates the dimensions of the kidney by controlling cell fate decisions at the interface between organ fields.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Cell lineage and cell cycling analyses of the 4d micromere using live imaging in the marine annelid Platynereis dumerilii

    B Duygu Özpolat et al.
    Lineage tracing at single-cell resolution reveals the presence of mesoteloblasts, the embryonic origin of mesodermal growth zone cells, and diverse cell cycling patterns of these lineages in the 'Polychaete' annelid Platynereis.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Concerted action of neuroepithelial basal shrinkage and active epithelial migration ensures efficient optic cup morphogenesis

    Jaydeep Sidhaye, Caren Norden
    Cellular and tissue level analysis reveals how different cell behaviors involving dynamics of the basal domain cooperate in space and time to shape an epithelial organ.