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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration

    Tisha E Bohr et al.
    Loss of a single organ, the planarian pharynx, triggers immediate proliferation and expansion of stem cells required to replace it.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    An updated phylogeny of the Alphaproteobacteria reveals that the parasitic Rickettsiales and Holosporales have independent origins

    Sergio A Muñoz-Gómez et al.
    Diverse sophisticated phylogenetic analyses update the phylogeny of the Alphaproteobacteria and show that the parasitic Holosporales is a derived group within the Rhodospirillales order which comprises primarily free-living alphaproteobacteria.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling

    Mark E Lush et al.
    Several support cell populations balance progenitor maintenance with differentiation in zebrafish lateral line sensory organs.
    1. Cancer Biology
    2. Cell Biology

    Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation

    Ashna Alladin et al.
    The presented primary epithelial acinus-based platform for studying interactions between normal and malignant cells will enable in depth analysis of the tumor initiation process on a molecular level.
    1. Cell Biology
    2. Computational and Systems Biology

    Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

    Jakub Tomek et al.
    A computer model of human cardiomyocyte was produced and validated on independent datasets, overcoming shortcomings of its predecessors, also yielding broadly relevant insights and results on major ionic currents.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Nuclei determine the spatial origin of mitotic waves

    Felix E Nolet et al.
    Nuclei and spatial system dimensions control local concentrations of cell cycle regulators, determining the spatial origin of waves that coordinate​ DNA replication and, subsequently, cell division.
    1. Genetics and Genomics
    2. Medicine

    Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

    Yi Liu et al.
    Systematic quantification of abdominal organ health parameters using deep learning generates new insights into the genetic architecture of cardiometabolic health traits.
    1. Cell Biology
    2. Developmental Biology

    Par3 cooperates with Sanpodo for the assembly of Notch clusters following asymmetric division of Drosophila sensory organ precursor cells

    Elise Houssin et al.
    Baz/Par3 and Sanpdo are required for clustering and activation of Notch receptors to allow intra-lineage private communication following asymmetric division of Drosophila epithelial cells.
    1. Cancer Biology

    Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism

    Krystal Ann Orlando et al.
    BRG1 loss drives initiation and progression in human cancers through changes in specific differentiation programs in an AP-1-dependent manner.
    1. Stem Cells and Regenerative Medicine

    Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria

    Carolyn E Adler et al.
    A chemical method has been developed for studying single organ regeneration and fate specification of stem cells in an adult organism.