Analysis of epigenome maps from human pancreatic progenitors and functional validation in zebrafish identify LAMA1 and CRB2 as type 2 diabetes risk-associated genes with roles in pancreatic development.
Emma M Briggs, Catarina A Marques ... Keith R Matthews
Single-cell transcriptomics of cryopreserved parasites reveals extensive cyclic regulation of mRNA abundance by Trypanosoma brucei during the cell cycle.
Vanessa Dumeaux, Samira Massahi ... Michael T Hallett
Candida albicans cells respond in two distinct ways to fluconazole exposure where cells enter the Ribo-dominant state characterized by an upregulation of ribosomal-related proteins and processes, or cells enter the Stress-dominant state characterized by the upregulation of stress responses.
Loss of the RNA-binding protein TDP-43 impairs the survival of oligodendrocyte progenitors and reactivates growth of mature oligodendrocytes, resulting in inappropriate wrapping of neuronal somata and blood vessels.
T-regulatory type 1 cells inherit a broad repertoire of epigenetic marks from T-follicular helper T-cells, offering new insights into the developmental biology of this subset.
Galina Popova, Hanna Retallack ... Tomasz Nowakowski
Combination of primary brain culture and single-cell RNA sequencing in brain organoids identifies microglia as the main target of rubella virus infection.
Paolo Petazzi, Telma Ventura ... Antonella Fidanza
A novel tool is used to assess gene function in vitro by targeted endogenous transcriptional activation to unveil novel players in development and disease.
Actin-independent water influx complements actin-driven cytoskeletal forces to potentiate chemoattractant-induced migration in primary human neutrophils.
The process of cytokinesis can allow cell lineages to intermix in mammalian epithelia, and cellular aspect ratio is a critical modulator of this behavior.
