1,333 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation

    Fabienne Lampert et al.
    Proteomic, biochemical and cell-based analyses of the heterodecameric core GID/CTLH E3 ligase complex reveal its molecular architecture, activity determinants, and function in targeting the tumor suppressor Hbp1 and other substrates required for cell proliferation.
    1. Cell Biology

    The cell proliferation antigen Ki-67 organises heterochromatin

    Michal Sobecki et al.
    Antigen Ki-67, which is widely used as a cell proliferation marker, controls heterochromatin organisation and gene expression.
    1. Developmental Biology

    miR-965 controls cell proliferation and migration during tissue morphogenesis in the Drosophila abdomen

    Pushpa Verma, Stephen M Cohen
    A microRNA-mediated mechanism coordinates cell proliferation with cell rearrangements during tissue morphogenesis.
    1. Chromosomes and Gene Expression

    The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress

    Takeshi Wakida et al.
    Minimizing anti-proliferation signaling from DNA damage detection machinery is the tactic for the cells to drive proliferation under genotoxic environment, and the function is exerted by Polo-Like-Kinase1 that is frequently over-expressed in cancer cells.
    1. Stem Cells and Regenerative Medicine

    Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

    Yunyun Jin et al.
    The Brahma chromatin remodelling complex interacts with the Hippo signalling pathway to regulate the proliferation and differentiation of stem cells in the Drosophila midgut.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut

    Chiwei Xu et al.
    In response to tissue damage, reactive oxygen species can be sensed by cation channels TRPA1/RyR to cause increases of cytosolic Ca2+ in intestinal stem cells, activating Ras/MAPK activity and stimulating stem cell proliferation in Drosophila.
    1. Cancer Biology
    2. Cell Biology

    MELK is not necessary for the proliferation of basal-like breast cancer cells

    Hai-Tsang Huang et al.
    The inhibitory or deletion effect of MELK does not impair the proliferation of basal-like breast cancer cell lines.
    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

    Bray Denard et al.
    Cleavage of a membrane-bound transcription factor by the chemotherapeutic reagent doxorubicin can block the proliferation of tumor cells.
    1. Structural Biology and Molecular Biophysics
    2. Cancer Biology

    A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression

    Elliot C Woods et al.
    Mucins, long associated with cancer aggression, remodel the cancer glycocalyx in a way that promotes proliferation in the metastatic site by enhancing integrin-mediated adhesion and thus driving cell cycle progression.
    1. Cancer Biology
    2. Cell Biology

    Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

    Sandra Kümper et al.
    The Rho kinases ROCK1 and 2 act redundantly in regulating cell proliferation and their depletion causes cellular senescence.

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