1,661 results found
    1. Human Biology and Medicine
    2. Stem Cells and Regenerative Medicine

    Insulin: Folding mutations suppress early beta-cell proliferation

    Honey Modi, James D Johnson
    Exploring how proliferation and maturation of beta-cells can be impaired after birth will shed light on the origins of various forms of diabetes.
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    1. Cell Biology

    The cell proliferation antigen Ki-67 organises heterochromatin

    Michal Sobecki et al.
    Antigen Ki-67, which is widely used as a cell proliferation marker, controls heterochromatin organisation and gene expression.
    1. Developmental Biology

    miR-965 controls cell proliferation and migration during tissue morphogenesis in the Drosophila abdomen

    Pushpa Verma, Stephen M Cohen
    A microRNA-mediated mechanism coordinates cell proliferation with cell rearrangements during tissue morphogenesis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation

    Fabienne Lampert et al.
    Proteomic, biochemical and cell-based analyses of the heterodecameric core GID/CTLH E3 ligase complex reveal its molecular architecture, activity determinants, and function in targeting the tumor suppressor Hbp1 and other substrates required for cell proliferation.
    1. Cancer Biology
    2. Cell Biology

    Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation

    Cong-Hui Yao et al.
    In addition to increasing glycolysis, some proliferating cells exhibiting the Warburg effect also increase oxidative phosphorylation through mitochondrial fusion.
    1. Chromosomes and Gene Expression

    The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress

    Takeshi Wakida et al.
    Minimizing anti-proliferation signaling from DNA damage detection machinery is the tactic for the cells to drive proliferation under genotoxic environment, and the function is exerted by Polo-Like-Kinase1 that is frequently over-expressed in cancer cells.
    1. Stem Cells and Regenerative Medicine

    Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle

    Sumiaki Fukuda et al.
    Proliferating muscle stem cells in overloaded muscle require special molecular mechanisms that differ from well-known myogenic differentiation model.
    1. Stem Cells and Regenerative Medicine

    Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

    Yunyun Jin et al.
    The Brahma chromatin remodelling complex interacts with the Hippo signalling pathway to regulate the proliferation and differentiation of stem cells in the Drosophila midgut.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut

    Chiwei Xu et al.
    In response to tissue damage, reactive oxygen species can be sensed by cation channels TRPA1/RyR to cause increases of cytosolic Ca2+ in intestinal stem cells, activating Ras/MAPK activity and stimulating stem cell proliferation in Drosophila.
    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

    Bray Denard et al.
    Cleavage of a membrane-bound transcription factor by the chemotherapeutic reagent doxorubicin can block the proliferation of tumor cells.

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