2,467 results found
    1. Cell Biology
    2. Genetics and Genomics

    Manipulation of the human tRNA pool reveals distinct tRNA sets that act in cellular proliferation or cell cycle arrest

    Noa Aharon-Hefetz et al.
    Systematic CRISPR-based editing of tRNA genes revealed that different human cells that span a range of growth rates and different modes of proliferation states require diverse tRNA sets.
    1. Chromosomes and Gene Expression

    PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells

    Payal Jain et al.
    Depletion of PHF19 in prostate cancer cells leads to an increase in MTF2 and PRC2 chromatin occupancy causing deregulation of key genes critical for proliferation and metastasis.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

    Hessel Honkoop et al.
    Single-cell RNA sequencing reveals Nrg1/ErbB2-induced metabolic reprogramming as a pivotal event for cardiomyocyte proliferation during heart regeneration.
    1. Developmental Biology

    miR-965 controls cell proliferation and migration during tissue morphogenesis in the Drosophila abdomen

    Pushpa Verma, Stephen M Cohen
    A microRNA-mediated mechanism coordinates cell proliferation with cell rearrangements during tissue morphogenesis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation

    Fabienne Lampert et al.
    Proteomic, biochemical and cell-based analyses of the heterodecameric core GID/CTLH E3 ligase complex reveal its molecular architecture, activity determinants, and function in targeting the tumor suppressor Hbp1 and other substrates required for cell proliferation.
    1. Cell Biology

    The cell proliferation antigen Ki-67 organises heterochromatin

    Michal Sobecki et al.
    Antigen Ki-67, which is widely used as a cell proliferation marker, controls heterochromatin organisation and gene expression.
    1. Cancer Biology
    2. Cell Biology

    Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation

    Cong-Hui Yao et al.
    In addition to increasing glycolysis, some proliferating cells exhibiting the Warburg effect also increase oxidative phosphorylation through mitochondrial fusion.
    1. Cancer Biology

    Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila

    Hiroshi Nishida et al.
    Src, an oncogene, promotes both cell proliferation and cell death simultaneously, which can be regulated by dietary methionine.
    1. Stem Cells and Regenerative Medicine

    Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

    Yunyun Jin et al.
    The Brahma chromatin remodelling complex interacts with the Hippo signalling pathway to regulate the proliferation and differentiation of stem cells in the Drosophila midgut.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

    Máté Nászai et al.
    Combined genetic experiments and cellular trafficking assays in Drosophila and mammalian models uncover a new role of RAS-like GTPases in EGFR signalling activation during tissue regeneration and tumourigenesis through regulation of EGFR internalisation.

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