21 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    Vertex sliding drives intercalation by radial coupling of adhesion and actomyosin networks during Drosophila germband extension

    Timothy E Vanderleest et al.
    Tricellular vertices possess sliding behaviors that harness radial forces and drive cell shape changes and intercalation in an epithelial tissue.
    1. Computational and Systems Biology
    2. Ecology

    Nomadic-colonial life strategies enable paradoxical survival and growth despite habitat destruction

    Zhi Xuan Tan, Kang Hao Cheong
    By modelling organisms that alternate between individual and colonial lifestyles, the well-known Parrondo's paradox can emerge in an ecological setting without the need for stochastic environmental variation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the mechanism of the DEAH-box RNA helicase Prp43

    Marcel J Tauchert et al.
    The structural and functional analysis of the ATP-dependent RNA helicase Prp43 provides insights into the mechanisms of RNA binding and translocation, which could serve as paradigm for all DEAH-box proteins.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mapping transiently formed and sparsely populated conformations on a complex energy landscape

    Yong Wang et al.
    Molecular simulations can capture key aspects of the conformational exchange in a protein.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanisms of nucleotide selection by telomerase

    Matthew A Schaich et al.
    The roles of key telomerase active site residues were elucidated to determine how telomerase selects the correct from the incorrect nucleotide to maintain telomere integrity.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Design principles of a microtubule polymerase

    Elisabeth A Geyer et al.
    Antagonism between binding to unpolymerized subunits and to the lattice leads to a ratcheting model for the processive action of a microtubule polymerase.
    1. Stem Cells and Regenerative Medicine

    Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss

    Judy Lisette Martin et al.
    A new platform for imaging live Drosophila adults yields vivid movies of the midgut over prolonged time scales, opening the door to the real-time study of organ renewal dynamics in a near-native context.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure in situ reveals a molecular switch that safeguards virus against genome loss

    Oliver W Bayfield et al.
    Structure of the portal protein of a thermostable virus, determined in its capsid-bound state, reveals a molecular mechanism that prevents DNA slippage during genome packaging.
    1. Structural Biology and Molecular Biophysics

    Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION

    Takanori Nakane et al.
    Multi-body refinement in RELION allows high-resolution reconstruction and visualisation of molecular motions in cryo-EM single-particle data sets with continuous forms of structural heterogeneity.
    1. Structural Biology and Molecular Biophysics

    Structural basis of mitochondrial translation

    Shintaro Aibara et al.
    Structural analysis of translating human mitoribosome illustrates elemental steps of translation in mitochondria.

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