2,135 results found
    1. Cell Biology
    2. Developmental Biology

    Planar cell polarity signaling coordinates oriented cell division and cell rearrangement in clonally expanding growth plate cartilage

    Yuwei Li, Ang Li ... Marianne Bronner
    Through the interaction between PCP signaling and N-cadherin, oriented cell division and cell rearrangement are coordinated to establish the appropriate tissue architecture critical for limb skeletal morphogenesis.
    1. Developmental Biology

    Emx2 regulates hair cell rearrangement but not positional identity within neuromasts

    Sho Ohta, Young Rae Ji ... Doris K Wu
    Emx2 is not required for sibling HCs to acquire their designated locations within the neuromast, inferring that Emx2 mediates opposite HC orientation by changing location of hair bundle establishment.
    1. Physics of Living Systems
    2. Developmental Biology

    Unified quantitative characterization of epithelial tissue development

    Boris Guirao, Stéphane U Rigaud ... Yohanns Bellaïche
    A new approach measures the respective participations of elementary cell behaviors – such as cell division, intercalation, shape change and death – in the shaping of animal tissues.
    1. Structural Biology and Molecular Biophysics

    Sterically confined rearrangements of SARS-CoV-2 Spike protein control cell invasion

    Esteban Dodero-Rojas, Jose N Onuchic, Paul Charles Whitford
    SARS-CoV-2 entry mechanism through membrane fusion is regulated by the spike protein glycosylation state.
    1. Cell Biology
    2. Genetics and Genomics

    Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

    Maja Kneissig, Kristina Keuper ... Zuzana Storchova
    A method to generate human cells with massive chromosomal aberrations on a specific chromosome allows analysis of their consequences.
    1. Cell Biology
    2. Developmental Biology

    Local mechanical forces promote polarized junctional assembly and axis elongation in Drosophila

    Jessica C Yu, Rodrigo Fernandez-Gonzalez
    Polarized assembly of cell-cell junctions drives Drosophila axis elongation.
    1. Developmental Biology
    2. Physics of Living Systems

    Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early Caenorhabditis elegans development

    Lokesh G Pimpale, Teije C Middelkoop ... Stephan W Grill
    Developmentally controlled chiral counter-rotating actomyosin flows drive cell-lineage spindle skews and cell rearrangements during cytokinesis in early nematode development.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility

    Chan-Wang Lio, Jiayuan Zhang ... Anjana Rao
    TET methylcytosine oxidases cooperate with B lineage-specific transcription factors to promote immunoglobulin gene rearrangement by depositing 5hmC, facilitating DNA demethylation and increasing chromatin accessibility at enhancers.
    1. Cell Biology
    2. Immunology and Inflammation

    Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires

    Yang Yang, Chunlin Wang ... Leonore A Herzenberg
    The B-1a cell heavy chain antibody repertoire differs dramatically from the follicular and marginal zone B cell repertoire and is defined by distinct mechanisms driven by self antigens rather than antigens derived from the microbiota.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Multiple sources of slow activity fluctuations in a bacterial chemosensory network

    Remy Colin, Christelle Rosazza ... Victor Sourjik
    Single-cell FRET measurements reveal large temporal activity fluctuations within this signaling pathway in Escherichia coli, caused by stochasticity of receptor methylation combined with allosteric interactions and slow rearrangements within receptor clusters.

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