2,620 results found
    1. Immunology and Inflammation

    RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

    Kirsteen M Tullett et al.
    Dendritic cell recognition and processing of antigens from dead cells, utilising the Clec9A-damage recognition receptor, is controlled by a novel RNF41-ubiquitin-mediated regulatory pathway.
    1. Cell Biology
    2. Immunology and Inflammation

    Small molecule inhibition of Csk alters affinity recognition by T cells

    Boryana N Manz et al.
    The T cell response, especially to weak agonists, is enhanced by acute Csk inhibition.
    1. Immunology and Inflammation

    Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses

    Shiho Chiba et al.
    An immune system pattern recognition receptor potentiates anti-tumor innate immune responses, offering new insight into anti-tumor activity of the innate immune system.
    1. Neuroscience

    A neural-level model of spatial memory and imagery

    Andrej Bicanski, Neil Burgess
    The BB model explains spatial cognition in terms of interactions between specific neuronal populations, providing a common computational framework for the human neuropsychological and in vivo animal electrophysiological literatures.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin

    Chao Yu Zhen et al.
    Live-cell single-molecule tracking reveals that hierarchical cooperation within the Polycomb Cbx7 protein between the low-affinity H3K27me3-binding module and the high-affinity DNA-binding cassette targets Polycomb repressive complex 1 to chromatin.
    1. Developmental Biology
    2. Neuroscience

    Birth order dependent growth cone segregation determines synaptic layer identity in the Drosophila visual system

    Abhishek Kulkarni et al.
    Timing in the formation of neurons influences synaptic connectivity.
    1. Chromosomes and Gene Expression

    The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

    Hsiang-Chen Chou et al.
    The initiation of human genome replication requires the six-subunit origin recognition complex (ORC) and CDC6, with ORC playing additional roles during mitosis and in organization of the cell nucleus.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    γ-Protocadherin structural diversity and functional implications

    Kerry Marie Goodman et al.
    Crystal structures of γ-protocadherin cell-cell recognition dimers reveal the determinants of clustered protocadherin homophilic specificity and cis interaction region structures alongside mutagenesis data identify the putative cis interface.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Cytoplasmic retention and degradation of a mitotic inducer enable plant infection by a pathogenic fungus

    Paola Bardetti et al.
    Degradation of a mitotic inducer coordinates the transition of two successive cell cycle arrests during the infective process of a plant pathogenic fungus.
    1. Cell Biology

    Two subunits of human ORC are dispensable for DNA replication and proliferation

    Etsuko Shibata et al.
    Human cell lines replicate and proliferate without ORC1 or ORC2, two subunits of the replication initiator protein complex ORC, which has till now been considered essential for DNA replication.

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