Computational simulations of actin network growth at the cell leading edge, combined with careful high-speed video microscopy measurements of leading edge shape fluctuations, suggest that Arp2/3 branching of the actin network occurs at an optimal angle to minimize fluctuations.
Olga Ibañez-Solé, Alex M Ascensión ... Ander Izeta
An increase in transcriptional noise generally assumed to characterize aged cells and tissues is shown to derive instead from technical and biological issues that underlie single-cell RNA sequencing experiments.
Cellular hallmarks of thermal limits are evolutionarily conserved in nematodes, and changes in surface to volume ratio reflect restricted aerobic metabolism at these limits.
Florian Heigwer, Christian Scheeder ... Michael Boutros
Genetic interaction analysis by combinatorial genetic perturbation and high-throughput imaging maps time- and context-dependent crosstalk between signaling pathways.
MreB filaments bind, orient, and move along the direction of greatest membrane curvature, thus orienting the insertion of new glycan strands around the cell circumference in a manner that may help establish and maintain rod shape.
Guillaume Ravel, Michel Bergmann ... Simon Labarthe
A new mathematical method has been developed, implemented and validated for the analysis of time-lapse confocal laser scanning microscopy images to characterize the swimming behavior of bacterial swimmers moving in the exogenous matrix of pathogenic biofilms.
Atle E Rimehaug, Alexander J Stasik ... Anton Arkhipov
A biophysically detailed model of mouse primary visual cortex reproduces, in a quantitative manner, experimentally recorded spikes and local field potentials, and suggests mechanisms that form current sinks and sources in vivo.
