5,257 results found
    1. Physics of Living Systems

    Ligand sensing enhances bacterial flagellar motor output via stator recruitment

    Farha Naaz et al.
    Sensing of ligands by chemoreceptors of Escherichia coli not only causes changes in the rotational bias of the flagellar motors but also increases motor speed via temporary recruitment of stators.
    1. Genetics and Genomics

    Whole-organism eQTL mapping at cellular resolution with single-cell sequencing

    Eyal Ben-David et al.
    The effect of genetic variation on gene expression can be specific down to the level of individual cells.
    1. Developmental Biology
    2. Immunology and Inflammation

    Identification of functionally distinct macrophage subpopulations in Drosophila

    Jonathon Alexis Coates et al.
    Drosophila macrophages are a heterogeneous population of cells containing subpopulations with enhanced responses to injury that display considerable variation in their abundance across development.
    1. Immunology and Inflammation

    Intravital quantification reveals dynamic calcium concentration changes across B cell differentiation stages

    Carolin Ulbricht et al.
    Heterogeneity in cytoplasmic calcium concentration alongside B cell activation and differentiation is measured intravitally using an interdisciplinary imaging approach and novel numerical analysis.
    1. Medicine
    2. Structural Biology and Molecular Biophysics

    Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics

    Ioannis Galdadas et al.
    A combination of equilibrium and nonequilibrium molecular dynamics simulations is an effective tool to study allosteric communications in ultrafast enzymes that show little or no conformational changes.
    1. Medicine
    2. Neuroscience

    Respiratory depression and analgesia by opioid drugs in freely behaving larval zebrafish

    Shenhab Zaig et al.
    Emerging approaches in larval zebrafish to identify safe opioid therapies without the side-effect of respiratory depression.
    1. Genetics and Genomics

    Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function

    William R Reay et al.
    Genetic data revealed existing drugs that could be repurposed to improve lung function, with evidence that compounds which control blood glucose could be particularly useful for respiratory impairment.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

    Luke Stephen Tain et al.
    Multi-omic profiling of gene expression in response to reduced insulin/IGF-like-signalling reveals tissue-specific regulation of DNA damage and lysosomal mannosidase regulation of tissue homeostasis as pro-longevity responses.

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