Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.
Biological aging processes and age-related diseases demonstrate sexual dimorphism where complex interactions between underlying aging mechanisms and sex chromosomes and hormones are seen in humans and animals.
Actively regulated immune memory differentiation, with a preference for cross-reactive receptors with moderate affinity against pathogens as opposed to high-affinity receptors, confers a long-term benefit to the host.
Differences in the lipid solvation energetics of associated and dissociated states is a primary driving force for membrane protein oligomerization, presenting a molecular mechanism for lipid regulation in biology.
Developing T cells whose TCRs have relatively low reactivity experience very brief TCR signaling events, experience delayed positive selection, and retaina preselection gene expression signature as they mature.