5,711 results found
    1. Cancer Biology

    Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues

    Teresa WM Fan et al.
    Pembrolizumab activates innate immune metabolism and function in primary human non-small cell lung cancer, whereas Pembrolizumab and beta-glucan synergize in enhancing immune metabolism and tumoridical action in brain-metastasized lung cancer.
    1. Structural Biology and Molecular Biophysics

    Structural insights into the activation of human calcium-sensing receptor

    Xiaochen Chen et al.
    The cryo-electron microscopy structures of inactive and active states of calcium-sensing receptor (CaSR) reveal the activation mechanisms of CaSR.
    1. Developmental Biology
    2. Evolutionary Biology

    Gamete expression of TALE class HD genes activates the diploid sporophyte program in Marchantia polymorpha

    Tom Dierschke et al.
    The ancestral mechanism to activate diploid gene expression via homeodomain transcription factors was retained in liverworts, an early diverging land plant lineage, and subsequently co-opted during evolution of the diploid sporophyte body.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

    Gaspare La Rocca et al.
    A new genetically engineered mouse strain is described in which miRNA activity can be acutely and reversibly inhibited, showing that in a subset of adult tissues miRNA activity is dispensable under homeostatic conditions but becomes essential during tissue regeneration.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

    Courtney Tindle et al.
    An integrated stem cell-based disease modeling and computational approach demonstrates how proximal airway epithelium is critical for SARS-CoV-2 infectivity and distal alveolar cells are critical for simulating the host responses.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

    Lizhi He et al.
    YAP and TAZ, the ultimate targets of the Hippo signaling pathway, are transcriptional co-activators of AP-1 proteins and STAT3 through which they are important for breast cellular transformation.
    1. Immunology and Inflammation

    Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes

    Alejandro J Brenes et al.
    In-depth proteomic analyses of intestinal tissue-resident intraepithelial T lymphocytes reveals how these cells are adapted to the intestinal environment through increased cholesterol and lipid metabolism, tailored metabolic profiles, receptors for interacting with epithelial cells, and tightly regulated signalling pathways.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

    Luka Bacic et al.
    Analysis of conformational heterogeneity in cryo-EM data by a recently developed deep learning method reveals the structure and dynamics of the oncogenic chromatin remodeler ALC1 bound to a poly-ADP-ribosylated nucleosome.

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