6,433 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Point of View: Is cell size a spandrel?

    Ariel Amir
    Analysis of experiments on bacteria suggests that the dependence of cell size on growth rate is not an adaptation but a causal consequence of a regulatory mechanism that controls DNA replication.
    1. Cell Biology
    2. Computational and Systems Biology

    Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity

    Miriam Bracha Ginzberg et al.
    Cells employ two strategies, adjusting both their cell cycle lengths and their growth rates in a size-dependent manner, to correct aberrations in cell size.
    1. Cell Biology

    Cortical regulation of cell size by a sizer cdr2p

    Kally Z Pan et al.
    It is shown that fission yeast cells sense their size by measuring their surface area through a membrane-associated sizer protein cdr2p.
    1. Cell Biology
    2. Plant Biology

    Auxin regulates SNARE-dependent vacuolar morphology restricting cell size

    Christian Löfke et al.
    Vacuolar morphologenesis correlates with cell size and is required for auxin-dependent inhibition of growth.
    1. Cell Biology
    2. Computational and Systems Biology

    Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length

    Shixuan Liu et al.
    The p38 MAPK pathway functions downstream of a cell-size-sensing process to coordinate cell size/growth with G1 progression in animal cells.
    1. Cell Biology
    2. Computational and Systems Biology

    Multiple inputs ensure yeast cell size homeostasis during cell cycle progression

    Cecilia Garmendia-Torres et al.
    Yeast cell size homeostasis is not controlled by a G1-specific mechanism alone but is likely to be an emergent property resulting from the integration of several mechanisms that coordinate cell and bud growth with division.
    1. Cell Biology

    Multi-phosphorylation reaction and clustering tune Pom1 gradient mid-cell levels according to cell size

    Veneta Gerganova et al.
    Advanced microscopy techniques reveal that clusters of Pom1 kinase at the membrane represent the functional unit that shape the concentration gradients and modulate Pom1 mid-cell levels according to cell size.
    1. Stem Cells and Regenerative Medicine

    Cell Division: Sibling cell size matters

    Clemens Cabernard
    A motor protein called Klp10A ensures that germline stem cells in male fruit flies divide to produce two sibling cells that are equal in size.
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    1. Cell Biology

    A new class of cyclin dependent kinase in Chlamydomonas is required for coupling cell size to cell division

    Yubing Li et al.
    CDKG1 is a D-cyclin dependent retinoblastoma related protein kinase whose abundance scales with cell size and controls cell division cycle number during multiple fission.
    1. Cell Biology

    Kinesin-6 regulates cell-size-dependent spindle elongation velocity to keep mitosis duration constant in fission yeast

    Lara Katharina Krüger et al.
    The scaling of spindle elongation velocity with cell size is regulated by the amounts of Kinesin-6 molecules and the number of binding sites for the motor to the mitotic spindle.

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