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    1. Cell Biology

    A new class of cyclin dependent kinase in Chlamydomonas is required for coupling cell size to cell division

    Yubing Li et al.
    CDKG1 is a D-cyclin dependent retinoblastoma related protein kinase whose abundance scales with cell size and controls cell division cycle number during multiple fission.
    1. Developmental Biology

    Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

    Néstor Saiz et al.
    A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
    1. Neuroscience

    Purkinje cell neurotransmission patterns cerebellar basket cells into zonal modules defined by distinct pinceau sizes

    Joy Zhou et al.
    Targeted genetic silencing and reporter labeling reveal that Purkinje cell activity organizes cerebellar basket cells into zonal modules based on the sizes of their projections.
    1. Cell Biology

    Kinesin-6 regulates cell-size-dependent spindle elongation velocity to keep mitosis duration constant in fission yeast

    Lara Katharina Krüger et al.
    The scaling of spindle elongation velocity with cell size is regulated by the amounts of Kinesin-6 molecules and the number of binding sites for the motor to the mitotic spindle.
    1. Physics of Living Systems

    Cell-sized confinement controls generation and stability of a protein wave for spatiotemporal regulation in cells

    Shunshi Kohyama et al.
    A cell-sized fully confined space significantly controls the emergence and stability of a protein wave, resulting in intracellular spatiotemporal regulation driven by a reaction-diffusion mechanism.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes

    Peter C de Greef et al.
    Combining experiments, bioinformatics, and mathematical modelling, we find large heterogeneity in naive T cell clone sizes.
    1. Computational and Systems Biology

    Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees

    Erika E Kuchen et al.
    The combination of statistical inference and perturbation experiments reveals that trans-generational inheritance of cell size and cell-cycle speed, coupled through a minimum-size checkpoint, shapes paradoxical cell-cycle correlations in lineage trees.
    1. Physics of Living Systems
    2. Immunology and Inflammation

    Early life imprints the hierarchy of T cell clone sizes

    Mario U Gaimann et al.
    The rapid development of immune memory in infancy shapes the composition of T cell defenses throughout the human lifespan.
    1. Cancer Biology
    2. Computational and Systems Biology

    Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes

    Rolando Ruiz-Vega et al.
    Spontaneous growth arrest of transformed melanocytes (resulting in benign “moles”) does not result from cell-autonomous oncogene-induced senescence, but can be explained by collective mechanisms used in normal tissue size control.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring

    Frauke Mücksch et al.
    PI(4,5)P2 plays a much broader role during the HIV-1 particle assembly process than assumed; it is indispensable not only for recruitment of Gag to the plasma membrane but also for the maintenance of Gag assemblies.