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    1. Developmental Biology
    2. Neuroscience

    TIAM-1/GEF can shape somatosensory dendrites independently of its GEF activity by regulating F-actin localization

    Leo TH Tang et al.
    The DMA-1/LRR-TM cell surface receptor signals through partially redundant pathways to cell-autonomously pattern dendrites, including by directly forming a complex with both the TIAM-1/GEF and ACT-4/Actin.
    1. Computational and Systems Biology
    2. Ecology

    Nomadic-colonial life strategies enable paradoxical survival and growth despite habitat destruction

    Zong Xuan Tan, Kang Hao Cheong
    By modelling organisms that alternate between individual and colonial lifestyles, the well-known Parrondo's paradox can emerge in an ecological setting without the need for stochastic environmental variation.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption

    John R Jimah et al.
    The structure, function and mechanism of the malaria vaccine candidate CelTOS reveal a unique pore-forming and membrane-disrupting protein with specificity for the inner leaflet of host and vector cells.
    1. Neuroscience

    PDF neuron firing phase-shifts key circadian activity neurons in Drosophila

    Fang Guo et al.
    A few circadian ‘evening’ neurons within the Drosophila brain play a key role in driving activity as well as keeping time, whereas the well-known PDF-containing morning cells are likely involved in integrating and transmitting light information.
    1. Neuroscience

    Complementary networks of cortical somatostatin interneurons enforce layer specific control

    Alexander Naka et al.
    Subtypes of dendrite-targeting somatostatin cells segregate into separate networks by specifically connecting with neurons in different layers, forming circuits that could independently control different input pathways to the neocortex.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

    Matthew J Shurtleff et al.
    A cell-free reaction that reconstitutes the selective sorting of a miRNA into exosomes reveals an RNA-binding protein, YBX1, as a critical sorting factor.
    1. Structural Biology and Molecular Biophysics

    Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves

    Rhys M Adams et al.
    The absolute affinities of thousands of variant antibodies are measured in parallel using a combination of cell sorting and high-throughput DNA sequencing.
    1. Microbiology and Infectious Disease

    Francisella tularensis enters a double membraned compartment following cell-cell transfer

    Shaun P Steele et al.
    Francisella tularensis spreads from cell to cell when macrophages engulf small portions of infected cells upon cell contact, forming distinctive a double membraned endosome containing multiple bacteria per individual vacuole.
    1. Neuroscience

    Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function

    Daniel Gerber et al.
    In the peripheral nervous system, the large GTPase dynamin 2 is required for Schwann cell survival, developmental radial sorting of axons, myelination, and myelin maintenance.
    1. Neuroscience

    Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling

    Mengchen Ye et al.
    Multivesicular bodies deliver long-range retrograde nerve growth factor (NGF) signals and serve as essential signaling and sorting platforms in the cell soma, and multivesicular body (MVB) cargoes dictate their vesicular fate.