Single mouse cytomegalovirus protein, m154, downmodulates surface expression of numerous targets important for NK and CD8 T cell activation by perturbing adaptor protein-1 sorting and redirecting targets to lysosomal degradation.
The structure, function and mechanism of the malaria vaccine candidate CelTOS reveal a unique pore-forming and membrane-disrupting protein with specificity for the inner leaflet of host and vector cells.
By modelling organisms that alternate between individual and colonial lifestyles, the well-known Parrondo's paradox can emerge in an ecological setting without the need for stochastic environmental variation.
A few circadian ‘evening’ neurons within the Drosophila brain play a key role in driving activity as well as keeping time, whereas the well-known PDF-containing morning cells are likely involved in integrating and transmitting light information.
Subtypes of dendrite-targeting somatostatin cells segregate into separate networks by specifically connecting with neurons in different layers, forming circuits that could independently control different input pathways to the neocortex.
Francisella tularensis spreads from cell to cell when macrophages engulf small portions of infected cells upon cell contact, forming distinctive a double membraned endosome containing multiple bacteria per individual vacuole.