The modularity and unequivocal input/response of Notch signaling are harnessed to measure cell-surface shedding of diverse transmembrane receptors to identify new proteolytic switches and detect modulation of proteolysis by therapeutics.

A robust fluorescence microscopy-based data acquisition and analysis framework affords the precise measurement of cell surface receptor affinities toward their cognate ligands and their densities in live cells/tissues.

Binding study of native adiponectin existing in serum supported the importance of T-cadherin but not AdipoRs nor calreticulin.

Genetic and biochemical analyses demonstrate that cell-surface lectin receptors can potentially function as extracellular NAD⁺-binding receptors and provide direct evidence for extracellular NAD⁺ being a bona fide endogenous signaling molecule in plants.

G protein-coupled odorant receptors regulate their own gene transcription based on their cell surface trafficking, which is facilitated by receptor transporting protein (RTP) family members.

A peptide motif targeting tumor-infiltrating macrophage in triple-negative breast cancer delays tumor growth and favors an antitumor immune response.

A cell surface receptor called Ret enables neurons to establish and maintain the organized arrays of dendrites that support communication between neurons.

Preferential endocytosis of activated receptors allows cells to memorize their past and perform relative sensing.

Ligand capture by cell surface receptor complexes sets the shape of the Nodal signaling pattern in zebrafish.

Engineered T cell receptors enable targeted immunotherapy with a reduced risk of harmful autoimmunity.